{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:31:00Z","timestamp":1783488660321,"version":"3.55.0"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T00:00:00Z","timestamp":1705276800000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Although the understanding of pre\u2010eclampsia (PE) has improved, there is still insufficient knowledge on the exact etiology and pathophysiological mechanisms. Dysregulation of angiogenic factors has emerged as a significant contributing factor. Among these factors, angiopoietins (Ang\u20101 and Ang\u20102) have gained considerable attention due to their crucial role in regulating vascular development and endothelial function. This study explored the maternal serum levels of angiopoietins and perinatal outcomes in PE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A case\u2010control study involving women with PE (cases) and normotensive pregnancies (controls) was conducted at the Maternity unit of the Korle\u2010Bu Teaching Hospital. Descriptive analysis was performed and the Mann\u2013Whitney U test (two\u2010sided) was used to compare maternal serum levels of angiopoietins between the cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 188 participants comprising 94 cases (women with PE) and 94 controls (normotensive pregnancies) with an average maternal age of 29.76\u2009\u00b1\u20095.56 and 28.43\u2009\u00b1\u20095.57 years, respectively. Maternal serum levels of Ang\u20102 were significantly lower among the PE cases compared\u00a0to the normotensive controls (1.25 [0.90, 2.15] vs. 2.14 [1.18, 5.73]\u2009ng\/mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) but no significant difference in Ang\u20101 levels (92.61 [80.92, 114.92] vs. 99.26 [81.76, 113.12]\u2009ng\/mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.429) was observed between the groups. The Ang\u20101\/Ang\u20102 ratio was significantly elevated among women with PE compared to normotensive controls (74.47 [37.69, 110.59] vs. 45.98 [16.11, 88.22]\u2009ng\/mL, <jats:italic>p<\/jats:italic>\u2009=\u20090.014). Also, women who delivered vaginally had significantly high maternal serum levels of Ang\u20101 compared to women who had cesarean section delivery (107.98\u2009\u00b1\u200927.79 vs. 89.02\u2009\u00b1\u200932.62\u2009ng\/mL).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal serum levels of Ang\u20102 but not Ang\u20101 were significantly depressed in women with PE compared to the pregnant normotensive controls. No significant associations were observed between Ang\u20101, Ang\u20102 levels, or the Ang\u20101\/Ang\u20102 ratio and pregnancy outcomes such as preterm birth, birth weight, and severity of hypertension.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.1806","type":"journal-article","created":{"date-parts":[[2024,1,15]],"date-time":"2024-01-15T09:49:46Z","timestamp":1705312186000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Maternal serum angiopoietins levels in pre\u2010eclampsia and pregnancy outcomes"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2703-8856","authenticated-orcid":false,"given":"Fidelis","family":"Bayor","sequence":"first","affiliation":[{"name":"Department of Physiology University of Ghana Medical School Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwame","family":"Adu\u2010Bonsaffoh","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Ghana Medical School Accra Ghana"},{"name":"Department of Obstetrics and Gynaecology University of Ghana Medical School Accra Ghana"},{"name":"Department of Obstetrics and Gynaecology Korle\u2010Bu Teaching Hospital Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Antwi\u2010Boasiako","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Ghana Medical School Accra Ghana"},{"name":"School of Nursing, College of Health Professionals and sciences University of Wisconsin\u2010Milwaukee Milwaukee Wisconsin USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,1,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preghy.2014.02.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.05.005"},{"key":"e_1_2_10_4_1","unstructured":"Ghana Statistical Service (GSS) Ghana Health Service (GHS) and ICF. 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