{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:47:37Z","timestamp":1792442857215,"version":"4.5.0"},"reference-count":53,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,4]],"date-time":"2024-02-04T00:00:00Z","timestamp":1707004800000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We compared the safety and efficacy of direct oral anticoagulants (DOACs) with those of warfarin in the long\u2010term (\u22656 months) treatment of cerebral venous thrombosis (CVT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We searched electronic databases up to November 2023 to compare the use of DOACs and warfarin in CVT management. Modified Rankin scores (mRS), new intracranial hemorrhage, all\u2010cause mortality, recurrence and nonrecanalisation events were used to assess outcome. RevMan v5.4 software and the Cochran\u2010Mantel\u2010Haenszel method were utilized to analyse data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 25 studies involving 2301 patients were identified as having treated CVT with either DOACs or warfarin. Good long\u2010term mRS scores 0\u20132 (risk ratio [RR]\u2009=\u20091.01, 95% CI\u2009=\u20090.98\u20131.03;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.61), new intracranial hemorrhage (RR\u2009=\u20091.00, 95% CI\u2009=\u20090.48\u20132.08;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.99), all\u2010cause mortality (RR\u2009=\u20091.00, 95% CI\u2009=\u20090.50\u20131.98;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.99), nonrecanalisation (RR\u2009=\u20090.95, 95% CI\u2009=\u20090.77\u20131.18;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.65) and recurrence venous thrombosis events (RR\u2009=\u20090.63, 95% CI\u2009=\u20090.33\u20131.22;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.17) were similar between the two treatment arms. Subgroup analysis found recurrence of venous thrombosis was lower in the rivaroxaban group compared to warfarin (2.2% vs. 8.5%, RR\u2009=\u20090.33, 95% CI\u2009=\u20090.11\u20130.98;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>DOACs and warfarin provide comparable long\u2010term safety and efficacy profiles. DOACs may be preferred over warfarin due to their ease of clinical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.1869","type":"journal-article","created":{"date-parts":[[2024,2,5]],"date-time":"2024-02-05T00:33:55Z","timestamp":1707093235000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Direct oral anticoagulants compared to warfarin in long\u2010term management of cerebral venous thrombosis: A comprehensive meta\u2010analysis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-5023","authenticated-orcid":false,"given":"Redoy","family":"Ranjan","sequence":"first","affiliation":[{"name":"Department of Cardiac Surgery Bangabandhu Sheikh Mujib Medical University Dhaka Bangladesh"},{"name":"Institute of Cardiovascular Research Royal Holloway University of London (ICR2UL) Greater London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gie","family":"Ken\u2010Dror","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Research Royal Holloway University of London (ICR2UL) Greater London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pankaj","family":"Sharma","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular Research Royal Holloway University of London (ICR2UL) Greater London UK"},{"name":"Department of Clinical Neurology Imperial College London Healthcare NHS Trust London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,2,4]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.671453"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MBC.0000000000000958"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13381"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000024"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1007903"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.123.044113"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/17474930211006303"},{"issue":"3","key":"e_1_2_18_9_1","first-page":"125","article-title":"Evaluation of rivaroxaban versus warfarin for the treatment of cerebral vein thrombosis: a case\u2010control blinded study","volume":"20","author":"Khorvash F","year":"2021","journal-title":"Curr J Neurol"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/21556660.2020.1838769"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2020003244"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ensci.2022.100412"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.121.037541"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4979210"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/1060028020952749"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-021-02091-1"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-021-01244-x"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760-021-01651-z"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.4088\/PCC.21m02927"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-021-02595-0"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2020.106204"},{"key":"e_1_2_18_22_1","first-page":"8487","article-title":"Comparison of warfarin and rivaroxaban in treatment of cerebral venous sinus thrombosis","volume":"6","author":"Saeed FA","year":"2019","journal-title":"Indo Am J Pharm Sci"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.5853\/jos.2019.00150"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502454"},{"key":"e_1_2_18_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/10760296221144038"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2022.11.001"},{"issue":"3","key":"e_1_2_18_27_1","first-page":"113","article-title":"Oral anticoagulation in cerebral venous sinus thrombosis\u2010experience from a tertiary care hospital in karnataka, south India. 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