{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:59:05Z","timestamp":1787320745964,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T00:00:00Z","timestamp":1707955200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>The acute tropical infectious disease known as yellow fever (YF) is caused by an arbovirus and is characterized by fever, jaundice, hemorrhage, headache, muscle pain, nausea, vomiting, and fatigue. Angola experienced a yellow fever virus (YFV) outbreak that was documented in December 2015. However, little is known about the outcome of this outbreak. We aimed to demonstrate epidemic features and lessons learned during the YF epidemic in Angola.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 4618 blood samples from suspected YF cases were sent to the Instituto Nacional de Investiga\u00e7\u00e3o em Sa\u00fade (INIS), a national referral and public health laboratory, between December 5, 2015, and December 23, 2016. Sample analyses were conducted using enzyme\u2010linked immunosorbent assay (ELISA) and reverse transcription polymerase chain reaction (RT\u2010PCR) assays. Blood samples were sent from 16 out of the 18 provinces of Angola.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We detected 884 (19.1%) cases that were positive for ELISA, which were confirmed by RT\u2010PCR assay. Considering the positive cases, the incidence among male patients was around three times higher (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009223; 10.9%) than in female patients (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200959; 2.6%) in the 20\u201329 age group, followed by the age group 10\u201319 with\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009211 (6.8%) in males versus\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009108 (3.3%) in females; and the age group 30\u201339 had\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200968 (4.8%) in males versus\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200928 (1.8%) in females. The other groups had an incidence below 3.0%. The case fatality ratio for YF was in young adults in the age group 20\u201329 with\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200939 cases, followed by the age group 10\u201319 with\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200916 cases, and finally the age group 0\u20139 with\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200913 cases. The other age groups had several deaths by YF below 10 cases.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This study demonstrates features of the YF epidemic that occurred in Angola. Also, it demonstrates that YF causes deaths in young people but is preventable by high vaccine coverage. Thus, public health laboratory surveillance must be strengthened to reduce the possibility of emerging and re\u2010emerging human infections.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.1924","type":"journal-article","created":{"date-parts":[[2024,2,15]],"date-time":"2024-02-15T04:25:39Z","timestamp":1707971139000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Assessment of the yellow fever outbreak in Angola from December 2015 through December 2016: A retrospective study"],"prefix":"10.1002","volume":"7","author":[{"given":"Eusebio","family":"Manuel","sequence":"first","affiliation":[{"name":"Faculdade de Medicina Universidade Agostinho Neto Luanda Angola"},{"name":"Direc\u00e7\u00e3o Nacional de Sa\u00fade P\u00fablica Minist\u00e9rio da Sa\u00fade Luanda 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