{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:49:52Z","timestamp":1785912592475,"version":"3.56.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,25]],"date-time":"2024-02-25T00:00:00Z","timestamp":1708819200000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","award":["IR.SUMS.MED.REC.1397.533"],"award-info":[{"award-number":["IR.SUMS.MED.REC.1397.533"]}],"id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Solar lentigines are common hyperpigmented lesions typically appearing after 50 years of age and associated with negative psychological effects in affected individuals. Topical depigmenting products, such as hydroquinone and even the Kligman's formula, are usually ineffective for treating lentigines. Stabilized cysteamine has been recently shown to be as effective as the modified Kligman's formula for treating melasma. In this study, we evaluated the therapeutic effect of a stabilized cysteamine on solar lentigines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A vehicle\u2010controlled, double\u2010blind, and randomized study was performed on 30 patients with solar lentigines. Stabilized cysteamine or vehicle control creams were applied on solar lentigines on the dorsum of the hands daily for 12 weeks. Clinical measurements with colorimetry and visual analog scale were performed at baseline, 4, 8, and 12 weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Statistically significant results were obtained in the cysteamine group versus the vehicle control group. Stabilized cysteamine provided a 40% reduction in colorimetric values (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.002) versus a 2% reduction in the vehicle group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.405). Cysteamine also provided a 40% reduction in VAS (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) versus a 2% reduction in the vehicle group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.245).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Significant improvement of solar lentigines was observed after 12 weeks of application of stabilized cysteamine by all evaluation methods. Stabilized cysteamine represents a highly effective topical treatment for solar lentigines and can be considered as one of the first topical therapies effective on this hyperpigmentary disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.1930","type":"journal-article","created":{"date-parts":[[2024,2,26]],"date-time":"2024-02-26T00:29:05Z","timestamp":1708907345000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Successful treatment of solar lentigines by topical application of stabilized cysteamine: A vehicle\u2010controlled, double\u2010blind randomized study"],"prefix":"10.1002","volume":"7","author":[{"given":"Nasrin","family":"Saki","sequence":"first","affiliation":[{"name":"Molecular Dermatology Research Center Shiraz University of Medical Sciences  Shiraz Iran"},{"name":"Department of Dermatology, School of Medicine Shiraz University of Medical Sciences Shiraz 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