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This review aims to explore the potential effects of vaccination on the oral microenvironment and classifies them as good, bad, or ugly, with a brief review of facial diseases following coronavirus disease 2019 (COVID\u201019) vaccination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a comprehensive review conducted through searching related articles in Medline, Scopus, and Google Scholar databases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>On one side, the \u201cGood\u201d impacts of vaccination on the oro\u2010nasal mucosa are explained as if the mucosal immune responses followed by SARS\u2010CoV\u20102 vaccines are enough to provide immunity. On the other side, the possible \u201cBad\u201d and \u201cUgly\u201d effects of the vaccine, which manifest as orofacial adverse events and autoimmune reactivations, respectively, should be noted. Exacerbation of pre\u2010existing autoimmune conditions such as lichen planus, pemphigus vulgaris, bullous pemphigoid, and Stevens\u2010Johnson syndrome have been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>COVID\u201019 vaccines could affect different biological systems alongside stimulating the immune system, and some of these effects are referred to as adverse effects. 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