{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T15:41:44Z","timestamp":1784302904601,"version":"3.55.0"},"reference-count":35,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T00:00:00Z","timestamp":1712102400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and aims<\/jats:title><jats:p>Oral lichen planus (OLP) is an inflammatory mucocutaneous disorder with an immune\u2010mediated pathogenesis. The tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1) level in the serum of OLP patients is significantly higher than in the control group. TNF\u2010\u03b1\u2010857 C\/T polymorphism can be related to the increased TNF\u2010\u03b1 level in blood circulation. This study investigated the relationship between TNF\u2010\u03b1 (\u2010857 C\/T) polymorphism and OLP patients in an Iranian population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Saliva samples were taken from 200 people, including 100 patients with OLP and 100 healthy people who did not have significant differences in age and sex. Then, DNA was extracted from them and the TNF\u2010\u03b1 (\u2010857 C\/T) genotype was identified using the polymerase chain reaction with confronting two\u2010pair primers method. Statistical Package for the Social Sciences version 16 software analyzed the results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The frequency of C\/C, C\/T, and T\/T genotypes of the TNF\u2010\u03b1\u2010857 C\/T polymorphism in the patient group were 78%, 18%, and 4%, respectively, and in the control group were 72%, 23%, and 5%, respectively. The differences between the two groups regarding allele (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009\u2009=\u2009\u20090.97, <jats:italic>p<\/jats:italic>\u2009\u2009=\u20090.32) and genotype (<jats:italic>\u03c7<\/jats:italic><jats:sup>2<\/jats:sup>\u2009\u2009=\u2009\u20090.96, <jats:italic>p<\/jats:italic>\u2009\u2009=\u20090.62) frequency among the studied population were insignificant.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that the difference in the frequency of\u00a0single nucleotide polymorphism TNF\u2010\u03b1\u2010857 C\/T polymorphism in the patient and control group had no significant relationship with the increased OLP incidence. Also, no significant association was observed between allele and genotype frequency of TNF\u2010\u03b1 (\u2010857 C\/T) with OLP subtypes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.2014","type":"journal-article","created":{"date-parts":[[2024,4,3]],"date-time":"2024-04-03T07:10:30Z","timestamp":1712128230000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessment of TNF\u2010\u03b1 (\u2010857 C\/T) gene polymorphism in oral lichen planus disease: A case\u2013control study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0429-4520","authenticated-orcid":false,"given":"Mohammad Hesam","family":"Marabi","sequence":"first","affiliation":[{"name":"Molecular Genetics Laboratory, Medical Biology Research Center, Health Technology Institute Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8592-7651","authenticated-orcid":false,"given":"Kheirollah","family":"Yari","sequence":"additional","affiliation":[{"name":"Molecular Genetics Laboratory, Medical Biology Research Center, Health Technology Institute Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9351-1499","authenticated-orcid":false,"given":"Hamid Reza","family":"Mozaffari","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Medicine, School of Dentistry Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2233-7280","authenticated-orcid":false,"given":"Masoud","family":"Hatami","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Medicine, School of Dentistry Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,4,3]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00946.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-03939-x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-023-03088-7"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1054\/bjom.2000.0335"},{"issue":"1","key":"e_1_2_12_6_1","first-page":"3","article-title":"Oral lichen planus: clinical features, etiology, treatment and management; 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