{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T15:17:29Z","timestamp":1780586249807,"version":"3.54.1"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,10]],"date-time":"2024-04-10T00:00:00Z","timestamp":1712707200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to examine maternal serum concentration of \u03b2\u2010human chorionic gonadotropin\u00a0(\u03b2\u2010hCG) on Day 16 after embryo transfer and risk of miscarriage, pre\u2010eclampsia, and intrauterine growth restriction (IUGR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we evaluated 125 pregnancies following in vitro fertilization (IVF). \u03b2\u2010hCG concentrations were measured on the morning of Day 16 after embryo transfer. Baseline characteristics of the study participants were also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Concentrations of \u03b2\u2010hCG on Day 16 after embryo transfer were inversely associated with the higher risk of miscarriage (<jats:italic>p<\/jats:italic> &lt;\u20090.001), but did not with pre\u2010eclampsia and IUGR (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Spearman's correlation coefficient showed a reverse and significant association between \u03b2\u2010hCG and higher risk of miscarriage (<jats:italic>\u03c3<\/jats:italic>\u2009=\u20090.531\u00a0and\u00a0<jats:italic>p\u2009<\/jats:italic>&lt;\u20090.001). There was a significant association between frozen embryo transfer and the risk of IUGR and pre\u2010eclampsia (<jats:italic>p<\/jats:italic>\u2009=\u20090.005\u00a0and <jats:italic>p<\/jats:italic>\u2009=\u20090.023, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Maternal serum concentrations of \u03b2\u2010hCG on Day 16 after IVF\/embryo transfer were associated with the higher risk of miscarriage, but not pre\u2010eclampsia and IUGR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.2015","type":"journal-article","created":{"date-parts":[[2024,4,11]],"date-time":"2024-04-11T04:39:41Z","timestamp":1712810381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Levels of serum \u03b2\u2010human chorionic gonadotropin after embryo transfer and subsequent miscarriage, pre\u2010eclampsia, and intrauterine growth restriction"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8677-2102","authenticated-orcid":false,"given":"Roya","family":"Kabodmehri","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Health Research Center, Al\u2010Zahra Hospital, School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0060-3955","authenticated-orcid":false,"given":"Nasrin","family":"Ghanami Gashti","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Reproductive Health Research Center, Al\u2010Zahra Hospital, School of Medicine Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5746-4269","authenticated-orcid":false,"given":"Ziba","family":"Zahiri 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