{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:13Z","timestamp":1753869253895,"version":"3.41.2"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005756","name":"Shahrekord University of Medical Sciences","doi-asserted-by":"publisher","award":["2869"],"award-info":[{"award-number":["2869"]}],"id":[{"id":"10.13039\/501100005756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Due to the concern about the side effects of chemical drugs and their ineffectiveness, the use of natural compounds as alternatives or complementary therapies has received increasing attention. The purpose of this study was to investigate the effect of <jats:italic>Nigella sativa<\/jats:italic> oil on the outcome of missed abortion.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this double\u2010blind clinical trial, 70 nulliparous pregnant women referred to Hajar Hospital and Imam Ali clinics of Shahrekord and had missed abortion before the 12\u2010week gestational age were selected and randomly divided into two interventions and control groups. The intervention group received 5 g\u00a0of <jats:italic>Nigella sativa<\/jats:italic> oil alone daily for up to 3 days and the control group received a placebo. In case of nonresponse, 3 days after the last dose of medication or placebo, 800 \u03bcg\u00a0of misoprostol (vaginal) were used. Data were analyzed by SPSS software. The chi\u2010square test, Fisher's exact test, independent <jats:italic>t<\/jats:italic>\u2010test and paired <jats:italic>t<\/jats:italic>\u2010test were used for analytical statistics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>According to the results, 18 cases (51.4%) in the intervention group and seven cases (20%) in the control group showed complete evacuation of uterine contents which had a significant difference (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The frequency of vagina physical examination and type of hemorrhage did not show any significant difference between the two groups before and after the intervention. After the intervention, human chorionic gonadotropin (HCG) was significantly decreased in the intervention group but did not change in the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The frequency of adverse events in the intervention group was three (8.6%) and in the control group was one (2.9%) which had no significant difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>Nigella sativa<\/jats:italic> improves the outcome of missed abortion by reducing HCG and facilitating cervix dilatation and delivery of uterine contents.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.2029","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T10:54:28Z","timestamp":1713351268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of the effect of <i>Nigella sativa<\/i> oil on the outcome of missed abortion in women: A randomized double\u2010blind clinical trial"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6100-4767","authenticated-orcid":false,"given":"Belgheis","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Clinical Research Development Unit, Hajar Hospital Shahrekord University of Medical Sciences Shahrekord Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila","family":"Nazari Robati","sequence":"additional","affiliation":[{"name":"Department of Medicine, Tehran Branch Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9743-4160","authenticated-orcid":false,"given":"Zeinab","family":"Tavakol","sequence":"additional","affiliation":[{"name":"Community\u2010Oriented Nursing Midwifery Research Center, Nursing and Midwifery School Shahrekord University of Medical Sciences Shahrekord Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5120-7082","authenticated-orcid":false,"given":"Mina","family":"Movahhed","sequence":"additional","affiliation":[{"name":"Department of Traditional Medicine, School of Traditional Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"volume-title":"Williams gynecology","year":"2020","author":"Hoffman BL","key":"e_1_2_12_2_1"},{"doi-asserted-by":"publisher","key":"e_1_2_12_3_1","DOI":"10.1186\/s40557-016-0140-1"},{"key":"e_1_2_12_4_1","first-page":"1243","article-title":"Management of spontaneous abortion","volume":"72","author":"Griebel CP","year":"2005","journal-title":"Am Fam Physician"},{"doi-asserted-by":"publisher","key":"e_1_2_12_5_1","DOI":"10.1186\/s13256-016-1029-x"},{"doi-asserted-by":"publisher","key":"e_1_2_12_6_1","DOI":"10.1016\/S0301-2115(02)00106-9"},{"doi-asserted-by":"publisher","key":"e_1_2_12_7_1","DOI":"10.3390\/diagnostics13020331"},{"doi-asserted-by":"publisher","key":"e_1_2_12_8_1","DOI":"10.1111\/jog.15201"},{"doi-asserted-by":"publisher","key":"e_1_2_12_9_1","DOI":"10.1097\/AOG.0000000000004063"},{"doi-asserted-by":"publisher","key":"e_1_2_12_10_1","DOI":"10.1111\/1471-0528.16737"},{"doi-asserted-by":"publisher","key":"e_1_2_12_11_1","DOI":"10.3310\/hta25680"},{"key":"e_1_2_12_12_1","first-page":"831","article-title":"The effect of saffron decoction consumption on pregnant mice and their offspring","volume":"19","author":"Dashti\u2010Rahmatabadi M","year":"2012","journal-title":"J Shahid Sadoughi Univ Med Sci"},{"issue":"2","key":"e_1_2_12_13_1","first-page":"27","article-title":"The effect of aqueous extract of borage (Anchusa Italica) on abortion in Syrian mice female wistar","volume":"8","author":"Zanganeh A","year":"2016","journal-title":"Journal Of Animal Biology"},{"volume-title":"Herbal medicine\u00a0use\u00a0during\u00a0pregnancy:\u00a0Benefits and untoward effects","year":"2018","author":"Laelago T","key":"e_1_2_12_14_1"},{"key":"e_1_2_12_15_1","first-page":"832","article-title":"Nigella sativa L. oil protects against induced hepatotoxicity and improves serum lipid profile in rats","volume":"50","author":"el\u2010Dakhakhny M","year":"2000","journal-title":"Arzneimittelforschung"},{"doi-asserted-by":"crossref","unstructured":"MukhtarH MumtazMW TauqeerT et al.Composition of Nigella sativa seeds. 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