{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T08:29:40Z","timestamp":1770884980177,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T00:00:00Z","timestamp":1713312000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Soil\u2010transmitted helminths are one of the most prevalent causes of both intellectual and physical disability in the world. Albendazole (ALB) is a drug recommended for mass treatment of the high burden of soil\u2010transmitted helminths in schoolchildren, particularly in developing countries. However, some researchers have reported that the efficacy of albedazole against soil\u2010transmitted helminths is inconsistent. Monitoring the programs is crucial to evaluating the effectiveness of 400\u2009mg of ALB against soil\u2010transmitted helminths, as well as any changes in its therapeutic efficacy. Thus, the purpose of this study was to evaluate ALB effectiveness in treating soil\u2010transmitted helminthes in Salgy Primary School Children.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An uncontrolled experimental study was conducted at Salgy Primary School Children, Northwest Ethiopia, from March to May 2020. A total of 439 schoolchildren were enrolled and screened for soil\u2010transmitted helminths by stratified proportionate systematic random sampling to get 228 positive schoolchildren. Students in grades one through eight were grouped based on their educational attainment. Using the Kato\u2010Katz thick smear technique, the selected stool sample collected from school children was examined using the Kato\u2010Katz thick smear technique to determine the cure and egg reduction rates. The statistical package for social science software, version 20, was used to analyze the data. To determine the relationship between CR (cure rate) and ERR (egg reduction rate) by age, a chi\u2010square test (<jats:italic>X<\/jats:italic><jats:sup>2<\/jats:sup>) was employed and significance was considered at A 95% confidence interval and <jats:italic>p<\/jats:italic> Value (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A 400\u2009mg single dosage of ALB showed a 99.35% CR and a 97.30% egg reduction rate against <jats:italic>Ascaris lumibricoides<\/jats:italic>. Additionally, a 400\u2009mg dose of ALB showed a 95.75% CR and an 82.07% egg reduction rate, suggesting questionable effectiveness against hookworm infections. <jats:italic>Trichuris trichiura<\/jats:italic> showed a decreased efficacy, with a 43.53% CR and a 23.12% egg reduction rate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single dose of 400\u2009mg ALB is effective (satisfactory), doubtful, and unsatisfactory against <jats:italic>Ascaris lumbricoides<\/jats:italic>, hookworm, and <jats:italic>T. trichiura<\/jats:italic> infections, respectively. Further studies using different brands, doses, and routes will be needed to treat hookworm and <jats:italic>T. trichiura<\/jats:italic> infections successfully by using a larger sample size.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.2041","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T10:58:26Z","timestamp":1713351506000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Efficacy of 400 mg albendazole against soil\u2010transmitted helminthes among Salgy Primary School Children, Dembia district, Northwest Ethiopia, 2020. \u201cUncontrolled experimental study\u201d"],"prefix":"10.1002","volume":"7","author":[{"given":"Adane","family":"Assefa","sequence":"first","affiliation":[{"name":"Department of Medical Parasitology, College of Medical and Health Sciences University of Gondar Gondar Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Demekech","family":"Damtie","sequence":"additional","affiliation":[{"name":"Department of Medical Parasitology, College of Medical and Health Sciences University of Gondar Gondar Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1624-3464","authenticated-orcid":false,"given":"Getu","family":"Abeje","sequence":"additional","affiliation":[{"name":"Department of Biomedical sciences, College of Medical and Health Sciences Samara University Samara Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4895-3017","authenticated-orcid":false,"given":"Andargachew","family":"Almaw","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Medical and Health Sciences Debre Tabor University Debre Tabor Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayenew","family":"Berhan","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Medical and Health Sciences Debre Tabor University Debre Tabor Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2512-4897","authenticated-orcid":false,"given":"Habtu","family":"Debsh","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Medical and Health Sciences Wollo University Dessie Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Molla","family":"Getie","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences, College of Medical and Health Sciences Inji\u2010bara University inje\u2010bara Ethiopia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,17]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Working to Overcome the Global Impact of Neglected Tropical Diseases: Control of Tropical Diseases","author":"World Health Organization","year":"1998"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0036-46652008000300003"},{"key":"e_1_2_12_4_1","volume-title":"Prevention of Schistosomiasis and Soil Transmited Helminthiasis. 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