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The mortality rate associated with CHC has been increasing due to the presence of comorbidities and the use of chronic medications. Therefore, the objective of this study was to investigate the impact of these comorbidities and chronic medications on the treatment plan for CHC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To achieve this objective, a cross\u2010sectional retrospective study was conducted at a tertiary hospital in Jeddah, Saudi Arabia. The study population included patients aged 12 years and above who were diagnosed with CHC between 2016 and 2021. Patients below the age of 12 were excluded from the study. A total of 170 patients with CHC were included in the analysis. The study aimed to evaluate the relationship between CHC complications and the treatment approach.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of the study participants was 66.78 years, with a higher proportion of female patients. The findings revealed a significant association between hypertension (<jats:italic>p<\/jats:italic>\u2009=\u20090.042) and cirrhosis (<jats:italic>p<\/jats:italic>\u2009=\u20090.007) with changes in the treatment plan for CHC. Moreover, the presence of diabetes mellitus (<jats:italic>p<\/jats:italic>\u2009=\u20090.045), renal diseases (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and hypothyroidism (<jats:italic>p<\/jats:italic>\u2009=\u20090.004) were significantly associated with HCV clearance after the initiation of therapy. Additionally, the use of proton pump inhibitors (<jats:italic>p<\/jats:italic>\u2009=\u20090.033) and levothyroxine (<jats:italic>p<\/jats:italic>\u2009=\u20090.025) was found to be associated with a higher rate of CHC clearance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, this study highlights the prevalence of comorbid conditions and the use of chronic medications among patients with CHC. The findings emphasize the importance of considering the effects of comorbidities and chronic medications when developing treatment plans for CHC infections. By taking these factors into account, healthcare professionals can optimize the management of CHC and improve patient outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.2055","type":"journal-article","created":{"date-parts":[[2024,4,29]],"date-time":"2024-04-29T07:40:20Z","timestamp":1714376420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Effects of comorbid conditions and prescribed chronic medications on the treatment plan for chronic hepatitis C infection: A cross\u2010sectional retrospective study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5362-1228","authenticated-orcid":false,"given":"Abdullah","family":"Awadh","sequence":"first","affiliation":[{"name":"Department of Basic Medical Sciences, College of Medicine King Saud Bin Abdulaziz University for Health and Sciences Jeddah Saudi Arabia"},{"name":"Department of Medical Education, College of Medicine King Saud Bin Abdulaziz University for Health and Sciences Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyad","family":"Badri","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud Bin Abdulaziz University for Health and Sciences Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nayef","family":"Alansari","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud Bin Abdulaziz University for Health and Sciences Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Alkhiri","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud Bin Abdulaziz University for Health and Sciences Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hussein","family":"Baharoon","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud Bin Abdulaziz University for Health and Sciences Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdelulah","family":"Niaz","sequence":"additional","affiliation":[{"name":"College of Medicine King Saud Bin Abdulaziz University for Health and Sciences Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Al\u2010Kathiri","sequence":"additional","affiliation":[{"name":"Research Unit, College of Medicine King Saud Bin Abdulaziz University for Health and Sciences Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enas","family":"Ghulam","sequence":"additional","affiliation":[{"name":"King Abdullah International Medical Research Center Jeddah Saudi Arabia"},{"name":"Department of Basic Sciences, College of Science and Health Professions King Saud Bin Abdulaziz University for Health and Sciences Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Medical Education, College of Medicine King Saud Bin Abdulaziz University for Health and Sciences Jeddah Saudi Arabia"},{"name":"King Abdullah International Medical Research Center Jeddah Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,4,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.24848"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2020.01.012"},{"key":"e_1_2_11_4_1","unstructured":"World Health Organization. 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