{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:20Z","timestamp":1753869260411,"version":"3.41.2"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T00:00:00Z","timestamp":1718064000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>This study aims to compare the effectiveness of thrombolytic therapy and anticoagulation in preventing chronic thromboembolic pulmonary hypertension (CTEPH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A total of 60 patients with intermediate\u2010high risk pulmonary embolism (PE) were randomly assigned to receive either thrombolytic therapy (<jats:italic>n<\/jats:italic>\u2009=\u200930) or anticoagulation (<jats:italic>n<\/jats:italic>\u2009=\u200930).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Echocardiographic assessments demonstrated no significant differences between the two treatment approaches in terms of right ventricular size (RVS) (on discharge in thrombolytic group: 31.17\u2009\u00b1\u20093.43 vs. anticoagulant group: 32.73\u2009\u00b1\u20095.27, <jats:italic>p<\/jats:italic>\u2009=\u20090.912), tricuspid annular plane systolic excursion (TAPSE) (on discharge in thrombolytic group: 17.66\u2009\u00b1\u20092.39 vs. anticoagulant group: 16.73\u2009\u00b1\u20092.93, <jats:italic>p<\/jats:italic>\u2009=\u20090.290), and systolic pulmonary artery pressure (SPAP) (on discharge in thrombolytic group: 32.93\u2009\u00b1\u20099.73 vs. anticoagulant group: 34.46\u2009\u00b1\u20099.30, <jats:italic>p<\/jats:italic>\u2009=\u20090.840). However, significant changes were observed in all assessed parameters within each treatment group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). The 6\u2010month follow\u2010up showed no significant difference between the two groups in terms of CTEPH incidence (<jats:italic>p<\/jats:italic>\u2009=\u20090.781) or functional class of the patients (<jats:italic>p<\/jats:italic>\u2009=\u20090.135).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Based on the findings of this study, neither thrombolytic therapy nor anticoagulation demonstrated superiority over the other in reducing adverse outcomes associated with intermediate\u2010high risk PE, including right ventricular size, SPAP, TAPSE, or CTEPH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.2093","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T17:22:55Z","timestamp":1718126575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Assessment of lytic therapy effect in patients with intermediate\u2010high risk pulmonary embolism for prevention of chronic thromboembolic pulmonary hypertension: A randomized, double\u2010blind trial"],"prefix":"10.1002","volume":"7","author":[{"given":"Pejman","family":"Mansouri","sequence":"first","affiliation":[{"name":"Hypertension Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amir Mohsen","family":"Rashidi","sequence":"additional","affiliation":[{"name":"Hypertension Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5714-254X","authenticated-orcid":false,"given":"Mohammad Hadi","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Hypertension Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masoumeh","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reihaneh","family":"Zavar","sequence":"additional","affiliation":[{"name":"Isfahan Cardiovascular Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afshin","family":"Amirpour","sequence":"additional","affiliation":[{"name":"Cardiac Rehabilitation Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyedeh Melika","family":"Hashemi","sequence":"additional","affiliation":[{"name":"Tehran Heart Center Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzieh","family":"Taheri","sequence":"additional","affiliation":[{"name":"Isfahan Cardiovascular Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/2045894018791358"},{"issue":"4","key":"e_1_2_10_3_1","first-page":"413","article-title":"Value of thrombolytic therapy for submassive pulmonary embolism patients","volume":"67","author":"Ahmed MA","year":"2018","journal-title":"Egypt J Chest Dis 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