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A systematic and comprehensive understanding of the link between BPD and suicide and self\u2010injury in adolescents and young adults is crucial for effective public health prevention strategies. This protocol outlines our approach to summarize the evidence on the association between BPD diagnosis and self\u2010injurious\/suicidal behaviors including death by suicide, nonfatal suicide attempts, NSSI, and self\u2010harm behavior through a systematic review and meta\u2010analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The protocol is registered (PROSPERO: CRD42022363329) and developed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta\u2010Analyses Protocols (PRISMA\u2010P)\u20102015 statement. We will conduct a comprehensive literature search using electronic databases including MEDLINE, EMBASE, SCOPUS, Web of Science, CINHAL, and PsycINFO. The review will include studies that meet the specific inclusion criteria and will be searched using multiple databases A meta\u2010analysis will be conducted using a fixed\u2010effects or random\u2010effects approach based on the level of heterogeneity. Subgroup analysis and meta\u2010regression will be performed if necessary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study is unique, as it is the first of its kind to systematically review and analyze the existing literature on this topic. The results of this study will provide important evidence on the magnitude of this relationship overall and in different subgroups, which can be used to inform the development of effective prevention and treatment strategies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.2143","type":"journal-article","created":{"date-parts":[[2024,6,11]],"date-time":"2024-06-11T16:49:51Z","timestamp":1718124591000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["The relationship between borderline personality disorder and self\u2010injurious\/suicidal behaviors in adolescents and young adults: A protocol for systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6869-8968","authenticated-orcid":false,"given":"Bhaskar","family":"Thakur","sequence":"first","affiliation":[{"name":"Department of Family and Community Medicine UT Southwestern Medical Center Dallas Texas USA"},{"name":"Peter O'Donnell Jr. School of Public Health UT Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mona","family":"Pathak","sequence":"additional","affiliation":[{"name":"Department of Pharmacotherapy UNT System College of Pharmacy Fort Worth Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chance","family":"Strenth","sequence":"additional","affiliation":[{"name":"Department of Family and Community Medicine UT Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Wilmoth","sequence":"additional","affiliation":[{"name":"Departments of Psychiatry and Physical Medicine &amp; Rehabilitation UT Southwestern Medical Center Dallas Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth Mayfield","family":"Arnold","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, College of Medicine University of Kentucky Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,6,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16770-6"},{"issue":"2","key":"e_1_2_8_3_1","first-page":"156","article-title":"Borderline personality disorder","volume":"105","author":"Mendez\u2010Miller M","year":"2022","journal-title":"Am Fam Physician"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1521\/pedi.2010.24.6.694"},{"key":"e_1_2_8_5_1","first-page":"1","volume-title":"Borderline personality disorder: treatment and management","author":"National Collaborating Centre for Mental Health","year":"2009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.158.2.295"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.157.3.472"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.29"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4088\/JCP.v69n0404"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.09.019"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2018.07.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1053\/comp.2001.26271"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2020.3598"},{"issue":"9","key":"e_1_2_8_14_1","first-page":"1","article-title":"Deaths: leading causes for 2019","volume":"70","author":"Heron M","year":"2021","journal-title":"National Vital Statistics Reports: From the Centers for Disease Control and Prevention, National Center for Health Statistics, National Vital Statistics System"},{"key":"e_1_2_8_15_1","unstructured":"XuJQ MurphySL KochanekKD AriasE.Mortality in the United States 2018(NCHS Data Brief no. 355). 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