{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T20:47:50Z","timestamp":1793047670366,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T00:00:00Z","timestamp":1719187200000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>There is a scarcity of evidence concerning the use of a prognostic instrument for predicting normal healing, delayed healing, and medication\u2010related osteonecrosis of the jaw (MRONJ) occurrence following tooth extraction in medically compromised patients. The present study aimed to predict healing outcomes following tooth extraction in medically compromised patients using an Adapted\u2010University of Connecticut osteonecrosis numerical scale (A\u2010UCONNS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The digital medical records of medically compromised patients were reviewed, who underwent tooth extraction. The A\u2010UCONNS parameters included the initial pathological condition, dental procedures, comorbidities (smoking habits, type and duration of medication, and type of intervention), and administered antiresorptive (AR) medications. Each parameter was assigned a different weight, and the scores were then accumulated and classified into three categories: minimal risk (less than 10), moderate risk (10\u221215), and significant risk (16 or more). The patient's healing status was categorized as normal healing, delayed healing, or MRONJ.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 353 male patients (mean age: 67.4 years) were recruited from a pool of 3977 patients, where 12.46% of patients had delayed wound healing, and 18.69% developed MRONJ. The median A\u2010UCONNS scores for MRONJ were higher based on initial pathology, comorbidity, and AR drugs compared to normal or delayed healing. In addition, a significant relationship existed between A\u2010UCONNS and healing outcomes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), with a unit increase in A\u2010UCONNS associated with 1.347 times higher odds of experiencing MRONJ compared to normal healing. In contrast, a low score was linked to an increased likelihood of normal wound healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The A\u2010UCONNS could act as a promising tool for predicting wound healing outcomes. It can provide clinicians the ability to pinpoint patients at high risk and allow tailoring of patient\u2010specific strategies for improving healing outcomes following tooth extraction.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.2184","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T12:29:55Z","timestamp":1719232195000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prediction of wound healing status following dental extraction using Adapted\u2010University of Connecticut osteonecrosis numerical scale: A retrospective study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9769-1914","authenticated-orcid":false,"given":"Isti R.","family":"Suryani","sequence":"first","affiliation":[{"name":"Department of Imaging &amp; Pathology, OMFS IMPATH Research Group, Faculty of Medicine, KU Leuven &amp; Oral and Maxillofacial Surgery University Hospitals Leuven Leuven Belgium"},{"name":"Department of Dentomaxillofacial Radiology, Faculty of Dentistry Universitas Gadjah Mada Yogyakarta Indonesia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6250-2650","authenticated-orcid":false,"given":"Sohaib","family":"Shujaat","sequence":"additional","affiliation":[{"name":"Department of Imaging &amp; Pathology, OMFS IMPATH Research Group, Faculty of Medicine, KU Leuven &amp; Oral and Maxillofacial Surgery University Hospitals Leuven Leuven Belgium"},{"name":"King Abdullah International Medical Research Center, Department of Maxillofacial Surgery and Diagnostic Sciences, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences Ministry of National Guard Health Affairs Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7228-466X","authenticated-orcid":false,"given":"Minh T.","family":"That","sequence":"additional","affiliation":[{"name":"Department of Imaging &amp; Pathology, OMFS IMPATH Research Group, Faculty of Medicine, KU Leuven &amp; Oral and Maxillofacial Surgery University Hospitals Leuven Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4290-4628","authenticated-orcid":false,"given":"Wim","family":"Coucke","sequence":"additional","affiliation":[{"name":"Heverlee Brugstraat Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3461-0363","authenticated-orcid":false,"given":"Reinhilde","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Department of Imaging &amp; Pathology, OMFS IMPATH Research Group, Faculty of Medicine, KU Leuven &amp; Oral and Maxillofacial Surgery University Hospitals Leuven Leuven Belgium"},{"name":"Department of Dental Medicine Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.02.001"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-016-0880-z"},{"issue":"2","key":"e_1_2_12_4_1","first-page":"403","article-title":"Cutaneous wound healing","volume":"59","author":"Chodorowska G","year":"2004","journal-title":"Ann Univ Mariae Curie\u2010Sklodowska, Sect D"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1017\/UPO9781922064004.024"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801238-3.99896-9"},{"issue":"4","key":"e_1_2_12_7_1","first-page":"215","article-title":"The non\u2010healing extraction socket: a diagnostic dilemma: case report and discussion","volume":"62","author":"Henry CJ","year":"2016","journal-title":"J Ir Dent Assoc"},{"issue":"3","key":"e_1_2_12_8_1","first-page":"1","article-title":"Clinical evaluation of post\u2010extraction","volume":"7","author":"Adeyemo WL","year":"2006","journal-title":"Cinical Eval. 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