{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T09:29:09Z","timestamp":1782552549419,"version":"3.54.5"},"reference-count":42,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T00:00:00Z","timestamp":1718755200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Further exploration is needed to recognize symptom clusters and categorize subgroups with distinct cluster patterns and associated risks, focusing on symptoms that are highly self\u2010reported by patients with breast cancer undergoing chemotherapy. This study aimed to identify subgroups and risk factors for self\u2010reported high symptom cluster burden among patients with breast cancer undergoing chemotherapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 647 participants who met the inclusion criteria were included in the study, with data collected on demographics, disease information, self\u2010reported symptoms, and psychosocial factors. Latent class analysis was utilized to identify the subgroup, while logistic regression was used to pinpoint predictive risk factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Latent class analysis revealed three subgroups: the \u201chigh burden of all symptoms group\u201d (<jats:italic>n<\/jats:italic>\u2009=\u2009107, 16.54%), the \u201chigh burden of psychological symptoms group\u201d (<jats:italic>n<\/jats:italic>\u2009=\u2009103, 15.92%), and the \u201clow burden of all symptoms group\u201d (<jats:italic>n<\/jats:italic>\u2009=\u2009437, 67.54%). Patients in the high burden of all symptom group and high burden of psychological symptom group exhibited significantly worse function outcomes (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Predictive risk factors for the \u201chigh burden of all symptom group\u201d included older age, lower self\u2010efficacy, worse body image, and a higher financial burden. Similarly, patients with high burden of psychological symptom were more likely to have low self\u2010efficacy, poor body image, and a high financial burden.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study demonstrated the importance of giving more attention to patients with breast cancer who are at risk of developing into membership of high symptom cluster burden group.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.2188","type":"journal-article","created":{"date-parts":[[2024,6,19]],"date-time":"2024-06-19T12:28:14Z","timestamp":1718800094000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Risk factors for self\u2010reported high symptom cluster burdens in patients with breast cancer undergoing chemotherapy in China: A cross\u2010sectional study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7113-0609","authenticated-orcid":false,"given":"Qingmei","family":"Huang","sequence":"first","affiliation":[{"name":"School of Nursing Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5384-3450","authenticated-orcid":false,"given":"Xuqian","family":"Zong","sequence":"additional","affiliation":[{"name":"School of Nursing Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8480-2569","authenticated-orcid":false,"given":"Changrong","family":"Yuan","sequence":"additional","affiliation":[{"name":"School of Nursing Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meimei","family":"Shang","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Yan","sequence":"additional","affiliation":[{"name":"Shandong Cancer Hospital and Institute Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeping","family":"Zheng","sequence":"additional","affiliation":[{"name":"Second Affiliated Hospital of Jiaxing University Jiaxing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meie","family":"Niu","sequence":"additional","affiliation":[{"name":"First Affiliated Hospital of Soochow University Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Fudan University Shanghai Cancer Center Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2197-3875","authenticated-orcid":false,"given":"Fulei","family":"Wu","sequence":"additional","affiliation":[{"name":"School of Nursing Fudan University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,6,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002108"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.31557\/APJCP.2019.20.7.2015"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000001474"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11121896"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-020-01591-x"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/apjon.apjon_51_18"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-018-0089-9"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3794"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/08870446.2021.1941960"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00002820-200507000-00005"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-020-05522-8"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmn.2018.09.005"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-016-3527-1"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2013.05.012"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpainsymman.2020.08.008"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/0193945916679812"},{"key":"e_1_2_13_19_1","first-page":"1","volume-title":"New Developments and Techniques in Structural Equation Modeling","author":"Muth\u00e9n B","year":"2001"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12955-022-01997-9"},{"key":"e_1_2_13_21_1","unstructured":"Health Measures. 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