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Multiple contributing risk factors for POD have been detected. Besides the predisposing factors such as higher age, cognitive impairment, high blood pressure, atrial fibrillation, and past stroke, pathophysiological mechanisms like neuroinflammation are also considered as contributing factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In a subanalysis of the \u201c<jats:styled-content>PR<\/jats:styled-content>e\u2010\n<jats:styled-content>O<\/jats:styled-content>perative\u00a0\n<jats:styled-content>P<\/jats:styled-content>rediction of postoperative\u00a0\n<jats:styled-content>DE<\/jats:styled-content>lirium by appropriate\u00a0\n<jats:styled-content>SC<\/jats:styled-content>reening\u201d (PROPDESC) study, the preoperative laboratory values of sodium, potassium, total protein, hemoglobin concentration (Hgb), and white blood cells as well as the biomarkers creatinine, HbA1c, NT\u2010pro\u2010BNP, high sensitive Troponin T (hsTnT), and C\u2010reactive protein (CRP) were assessed to investigate a possible relationship to the occurrence of POD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After correction for age, physical status classification, surgery risk after Johns Hopkins, and operative discipline (cardiac surgery vs. noncardiac surgery), male patients with a Hgb &lt;13\u2009g\/dL had significantly higher odds for POD (<jats:italic>p<\/jats:italic>\u2009=\u20090.025). Furthermore, patients with CRP\u2009\u2265\u200910\u2009mg\/L, HbA1c value\u2009\u2265\u20098.5% as well as patients with hypernatraemia (&gt;145\u2009mmol\/L) presented significantly higher odds to develop POD (<jats:italic>p<\/jats:italic>\u2009=\u20090.011, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001, and <jats:italic>p<\/jats:italic>\u2009=\u20090.021, respectively). A raised (&gt;14\u221252\u2009ng\/L) or high (&gt;52\u2009ng\/L) hsTnT value was also associated with a significantly higher chance for POD compared to the patient group with hsTnT &lt;14\u2009ng\/L (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 and <jats:italic>p<\/jats:italic>\u2009=\u20090.016, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Preoperative Hgb, CRP, HbA1c, sodium, and hsTnT could be used to complement and refine the preoperative screening for patients at risk for POD. Further studies should track these correlations to investigate the potential of targeted POD protection and enabling hospital staff to initiate POD\u2010preventing measures in time.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.2219","type":"journal-article","created":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T10:23:56Z","timestamp":1719829436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Predictiveness of preoperative laboratory values for postoperative delirium"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6466-9780","authenticated-orcid":false,"given":"Vera","family":"Guttenthaler","sequence":"first","affiliation":[{"name":"Clinic of Anaesthesia and Intensive Care Medicine University Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4978-5555","authenticated-orcid":false,"given":"Jacqueline","family":"Fidorra","sequence":"additional","affiliation":[{"name":"Clinic of Anaesthesia and Intensive Care Medicine University Bonn Bonn Germany"},{"name":"Asklepios Clinic North Heidberg Clinic for Internal Medicine Department I Hamburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4786-7712","authenticated-orcid":false,"given":"Maria","family":"Wittmann","sequence":"additional","affiliation":[{"name":"Clinic of Anaesthesia and Intensive Care Medicine University Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1525-6450","authenticated-orcid":false,"given":"Jan","family":"Menzenbach","sequence":"additional","affiliation":[{"name":"Clinic of Anaesthesia and Intensive Care Medicine University Bonn Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000107"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.005"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1605501"},{"key":"e_1_2_10_5_1","unstructured":"ICD\u201011 for mortality and morbidity statistics [Internet].2023.https:\/\/icd.who.int\/browse11\/l-m\/en#\/http%3a%2f%2fid.who.int%2ficd%2fentity%2f897917531"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.06.063"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2012.6857"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000594"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000021595"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-018-2517-8"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e3281e38774"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevImmunol.v31.i4.30"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0136071"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/gps.327"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13018-020-02035-4"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.10062"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/icvts\/ivt323"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/EA9.0000000000000022"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2022.05.032"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/61.12.1294"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1819.2003.01126.x"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/chf.12007"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1155\/2012\/367516"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conctc.2019.100501"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinane.2022.110684"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeh210"},{"key":"e_1_2_10_27_1","unstructured":"Deutsche Diabetes Gesellschaft. 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