{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:31Z","timestamp":1753869271051,"version":"3.41.2"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013327","name":"H. Lundbeck A\/S","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013327","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Patients with neurogenic orthostatic hypotension (nOH) due to autonomic dysfunction may also experience supine hypertension (defined as supine systolic blood pressure [SBP] \u2265140\u2009mmHg). Because pressor agents used to improve nOH symptoms by increasing standing blood pressure (BP) may exacerbate or cause supine hypertension, changes in supine BP with nOH treatments are of interest.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This post hoc study examined changes in SBP in patients receiving droxidopa (100\u2010600\u2009mg, three times daily) during a 12\u2010month long\u2010term extension study based on whether patients had supine hypertension (ie, supine SBP \u2265140\u2009mmHg) at baseline. Shifts from baseline in supine hypertension categorization and mean supine and standing SBP after 6 and 12\u2009months of treatment with droxidopa were determined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, 64 patients did not have supine hypertension (mean supine SBP, 120\u2009mmHg) and 38 patients had supine hypertension (mean supine SBP, 157\u2009mmHg). A similar percentage of patients shifted from their respective baseline supine hypertension categorization (ie, with or without supine hypertension) to the other category after receiving droxidopa for 6 or 12\u2009months. After 12\u2009months of droxidopa treatment, patients with supine hypertension at baseline had a mean supine SBP decrease of 3\u2009mmHg and a mean standing SBP increase of 9\u2009mmHg. Patients without supine hypertension at baseline had mean supine and standing SBP increases of 12 and 15\u2009mmHg, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was no consistent or progressive elevation in supine SBP over time during the 12\u2010month treatment with droxidopa in patients either with or without supine hypertension at baseline. These data suggest that long\u2010term droxidopa treatment for nOH does not adversely affect supine BP.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.227","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T19:24:17Z","timestamp":1611170657000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterization of the changes in supine blood pressure with <scp>long\u2010term<\/scp> use of droxidopa in patients with neurogenic orthostatic hypotension"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1201-842X","authenticated-orcid":false,"given":"L. Arthur","family":"Hewitt","sequence":"first","affiliation":[{"name":"Lundbeck  Deerfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Lindsten","sequence":"additional","affiliation":[{"name":"Lundbeck A\/S  Copenhagen Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Gorny","sequence":"additional","affiliation":[{"name":"Lundbeck  Deerfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2981-7837","authenticated-orcid":false,"given":"Meghana","family":"Karnik\u2010Henry","sequence":"additional","affiliation":[{"name":"Lundbeck  Deerfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven","family":"Kymes","sequence":"additional","affiliation":[{"name":"Lundbeck  Deerfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonella","family":"Favit","sequence":"additional","affiliation":[{"name":"Lundbeck  Deerfield Illinois"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,1,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-018-0529-8"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0119-5"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-016-8375-x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-018-1129-x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(99)05320-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-015-0324-8"},{"issue":"5","key":"e_1_2_11_8_1","first-page":"473","article-title":"The impact of supine hypertension on target organ damage and mortality in patients with neurogenic orthostatic hypotension","volume":"28","author":"Palma JA","year":"2018","journal-title":"Clin Auton Res"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)30079-5"},{"volume-title":"Full Prescribing Information","year":"2017","author":"Northera\u00ae (droxidopa)","key":"e_1_2_11_10_1"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.114.04035"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000615"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-160860"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-011-0146-2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12883-017-0867-5"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jash.2016.07.010"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.227","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,2]],"date-time":"2023-09-02T10:06:14Z","timestamp":1693649174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1,20]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/hsr2.227"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.227","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"type":"print","value":"2398-8835"},{"type":"electronic","value":"2398-8835"}],"subject":[],"published":{"date-parts":[[2021,1,20]]},"assertion":[{"value":"2020-10-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e227"}}