{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T15:45:35Z","timestamp":1759938335402,"version":"3.41.2"},"reference-count":36,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T00:00:00Z","timestamp":1617840000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postherpetic neuralgia (PHN) is the most common and bearable complication of herpes zoster (HZ). This pain may have negative impact on the patient's all aspects of daily life and health\u2010related quality of life (HRQOL). Despite numerous advances in treatment, many patients remain resistant to the current therapy options. It is the first time subcutaneous injection of methylprednisolone acetate and lidocaine has been used to treat <jats:italic>refractory<\/jats:italic> PHN. We report the results of this treatment evaluating pain relief and HRQOL improvement in this disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 43 patients with refractory PHN was enrolled in the observational study. All patients received daily subcutaneous injection of methylprednisolone acetate and lidocaine for 10 consecutive days. The severity of pain was assessed by using Visual Analog Scale (VAS), and 36\u2010Item Short Form Survey (SF\u201036) was applied to evaluate HRQOL. Assessment of the pain and HRQOL was carried out at baseline and posttreatment at 4\u2009weeks as well as 6 and 12\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At baseline, all patients experienced severe PHN with average VAS scores of 8.44\u2009\u00b1\u20090.85 (minimum 7; maximum 10). At 4\u2009weeks, 6\u2009months, and 12\u2009months after treatment, the pain had significantly decreased (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001), and all subjects showed significant improvement in all eight domains of HRQOL. No major adverse events associated with the subcutaneous injection were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results indicate that subcutaneous injection of methylprednisolone acetate and lidocaine can be an effective and safe treatment for PHN.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.271","type":"journal-article","created":{"date-parts":[[2021,4,8]],"date-time":"2021-04-08T20:19:15Z","timestamp":1617913155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The effect of subcutaneous injection of methylprednisolone acetate and lidocaine for refractory postherpetic neuralgia: a prospective, observational study"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9936-1954","authenticated-orcid":false,"given":"Duc Thuan","family":"Nguyen","sequence":"first","affiliation":[{"name":"Department of Neurology Military Hospital 103, Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thanh Chung","family":"Dang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quang An","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Stroke Center Phu Tho General Hospital  Viet Tri Phu Tho Province Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4723-5029","authenticated-orcid":false,"given":"Trung Duc","family":"Le","sequence":"additional","affiliation":[{"name":"Department of Neurology Military Hospital 103, Vietnam Military Medical University  Hanoi Vietnam"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thi Dung","family":"Hoang","sequence":"additional","affiliation":[{"name":"Department of Neurology Military Hospital 103, Vietnam 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