{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T03:50:58Z","timestamp":1776743458816,"version":"3.51.2"},"reference-count":9,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T00:00:00Z","timestamp":1626393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Due to the popularity of excessive alcohol consumption, there is an increasing need for hangover symptom remedies. Most commercially available hangover treatment products have not been tested for efficacy through clinical study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of this pilot study was to characterize the activity of a commercially available hangover product, The Hangover Secret (THS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a randomized, double\u2010blinded, placebo\u2010controlled, crossover pilot study. Healthy volunteers of 21\u2010 to 40\u2010years\u2010old were eligible for participation, and received either THS or placebo on two different occasions. Participants were given 43 mL of whiskey every twenty minutes for up to 3\u2009hours to achieve a blood alcohol concentration (BrAC) \u2265\u20090.12%. Hangover severity was assessed using the Acute Hangover Scale (AHS) and Acute Hangover Severity Scale (AHSS) validated tools.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Nine participants completed the study. AHS scores increased from baseline to 7\u00a0<jats:sc>AM<\/jats:sc> by 4.11 \u00b1\u20093.17 and 1.26 \u00b1\u20092.29 for the placebo and active arms respectively (<jats:italic>P<\/jats:italic> = .16). AHS headache scores increased from baseline to 7\u00a0<jats:sc>AM<\/jats:sc> by 2.44 \u00b1\u20091.67 and 1.11 \u00b1\u20091.17 for the placebo and active arms respectively (<jats:italic>P<\/jats:italic> = .06). AHSS scores increased from baseline to 7\u00a0<jats:sc>AM<\/jats:sc> by 1.0 \u00b1\u20091.05 and 0.41 \u00b1\u20091.08, for the placebo and active arms respectively (<jats:italic>P<\/jats:italic> = .30). There was no significant difference between average BrAC at 7\u00a0<jats:sc>AM<\/jats:sc> between the placebo and active arms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>THS showed positive signals in the prevention of alcohol\u2010induced hangover, especially headaches. The improvements with THS surpassed the minimum clinically important difference in overall AHS score and three individual AHS symptoms scores (hangover, headache, and thirsty). THS's reduction in AHS or AHSS scores did not reach statistical significance likely due to the small sample size. Larger studies with appropriate sample sizes are needed in light of these promising findings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.330","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T13:22:49Z","timestamp":1626441769000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effects of the hangover secret on mitigating hangover symptoms: A pilot study"],"prefix":"10.1002","volume":"4","author":[{"given":"Der Yu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmacy Practice Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific  Stockton California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheel","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific  Stockton California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberly","family":"Maiton","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific  Stockton California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Pham","sequence":"additional","affiliation":[{"name":"Clinical Investigations Facility; David Grant USAF Medical Center  Travis AFB California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate M.","family":"O'Dell","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific  Stockton California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy N.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific  Stockton California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5850-1113","authenticated-orcid":false,"given":"Sachin A.","family":"Shah","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Practice Thomas J. Long School of Pharmacy and Health Sciences, University of the Pacific  Stockton California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,7,16]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030823"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.1990.51.389"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.15288\/jsa.2006.67.147"},{"key":"e_1_2_11_5_1","unstructured":"GreenJ KalischA.Milk thistle (Silybum marianum) Cam\u2010Cancer.http:\/\/www.cam-cancer.org\/The-Summaries\/Herbal-products\/Milk-thistle-Silybum-marianum"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ALC.0000085585.81711.AE"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-012-2866-y"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2006.10.001"},{"key":"e_1_2_11_9_1","unstructured":"Communicating Drink Information.http:\/\/www.ccdus.ca\/Eng\/topics\/alcohol\/Communicating-Drink-Information\/Pages\/default.aspx"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9040932"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.330","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:18:29Z","timestamp":1693297109000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,16]]},"references-count":9,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/hsr2.330"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.330","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,16]]},"assertion":[{"value":"2020-11-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e330"}}