{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T20:06:17Z","timestamp":1790107577576,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T00:00:00Z","timestamp":1628467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Blood pressure lability has been observed in certain cohorts of pediatric patients with variable degrees of proteinuria; however, the impact of proteinuria on blood pressure is not fully elucidated. The objective of our study was to analyze blood pressure and heart rate in pediatric patients with proteinuria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We performed a retrospective chart review of patients (age 1\u201018) diagnosed with idiopathic nephrotic syndrome, with varying degrees of proteinuria. Blood pressure and heart rate data were analyzed in relation to anthropometric and biochemical parameters. A total of 72 urine sample analyses, along with associated blood pressure measurements, were obtained from the charts of 33 children (males\u00a0=\u00a025).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Diastolic blood pressure <jats:italic>Z<\/jats:italic>\u2010scores were significantly higher in proteinuric patients (urine protein\/creatinine &gt;0.02\u2009g\/mmol) compared to non\u2010proteinuric patients (<jats:italic>P<\/jats:italic>\u00a0=\u2009.006; Cohen\u2010<jats:italic>d<\/jats:italic> 0.97 [0.41; 1.53]). Systolic blood pressure was also significantly higher in proteinuric patients (<jats:italic>P<\/jats:italic>\u00a0=\u2009.04), but with a less significant effect size (Cohen\u2010<jats:italic>d<\/jats:italic> 0.54 [\u22120.002; 1.08]). Proteinuria (&gt;0.02\u2009g\/mmol) was the most significant predictor of diastolic (<jats:italic>\u03b2<\/jats:italic>\u00a0=\u2009.79, <jats:italic>P<\/jats:italic>\u00a0=\u2009.04), but not systolic blood pressure elevation on multivariate analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed a disproportionate increase in diastolic blood pressure vs systolic blood pressure in patients with proteinuria.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.346","type":"journal-article","created":{"date-parts":[[2021,8,9]],"date-time":"2021-08-09T19:47:48Z","timestamp":1628538468000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Diastolic hypertension is associated with proteinuria in pediatric patients"],"prefix":"10.1002","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6441-8612","authenticated-orcid":false,"given":"Robert L.","family":"Myette","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, Children's Hospital of Eastern Ontario University of Ottawa  Ottawa Ontario Canada"},{"name":"Kidney Research Center, Department of Cellular and Molecular Medicine, The Ottawa Hospital Research Institute University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dylan","family":"Burger","sequence":"additional","affiliation":[{"name":"Kidney Research Center, Department of Cellular and Molecular Medicine, The Ottawa Hospital Research Institute University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavel","family":"Geier","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, Children's Hospital of Eastern Ontario University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3687-6691","authenticated-orcid":false,"given":"Janusz","family":"Feber","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Pediatrics, Children's Hospital of Eastern Ontario University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,9]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/pir.36-3-117"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2019.00287"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000238823"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10157-018-1565-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.117.10050"},{"key":"e_1_2_10_7_1","first-page":"1999","article-title":"Resting pulse rate reference data for children, adolescents, and adults: United States, 1999\u20102008","volume":"41","author":"Ostchega Y","year":"2011","journal-title":"Natl Health Stat Report"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01026"},{"issue":"3","key":"e_1_2_10_9_1","first-page":"500","article-title":"Blood pressure in minimal change and other types of nephrotic syndrome","volume":"12","author":"Kuster S","year":"1990","journal-title":"Clin Exp Hypertens Part A Theory Pract"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.06260614"},{"issue":"3","key":"e_1_2_10_11_1","first-page":"461","article-title":"The nephrotic syndrome in adults with \u2018minimal change\u2019 glomerular lesions","volume":"43","author":"Cameron JS","year":"1974","journal-title":"QJM"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00467-006-0413-y"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/ki.1981.209"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.108.110635"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.116.07289"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.346","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:19:03Z","timestamp":1693297143000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,9]]},"references-count":14,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/hsr2.346"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.346","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,9]]},"assertion":[{"value":"2021-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e346"}}