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MiRNAs have been investigated for many years in various skin disorders such as atopic dermatitis, psoriasis, as well as malignant tumors. Only during recent times, cosmeceutical use of molecules\/natural active ingredients to regulate miRNA expression for significant advances in skin health\/care product development was recognized.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To review miRNAs with the potential to maintain and boost skin health and avoid premature aging by improving barrier function, preventing photoaging, hyperpigmentation, and chronological aging\/senescence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Most of the cited articles were found through literature search on PubMed. The main search criteria was a keyword \u201cskin\u201d in combination with the following words: miRNA, photoaging, UV, barrier, aging, exposome, acne, wound healing, pigmentation, pollution, and senescence. Most of the articles reviewed for relevancy were published during the past 10\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All results are summarized in Figure 1, and they are based on cited references.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Thus, regulating miRNAs expression is a promising approach for novel therapy not only for targeting skin diseases but also for cosmeceutical interventions aiming to boost skin health.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.374","type":"journal-article","created":{"date-parts":[[2021,10,15]],"date-time":"2021-10-15T17:21:44Z","timestamp":1634318504000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Targeting <scp>microRNA<\/scp> for improved skin health"],"prefix":"10.1002","volume":"4","author":[{"given":"Xi","family":"Li","sequence":"first","affiliation":[{"name":"Oriflame Cosmetics AB; Skin 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