{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:53:26Z","timestamp":1753869206151,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>Using a lung sound analysis, the prognosis of asthma was investigated in infants with risk factors for asthma development by a long\u2010term observation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 268 infants were included (median age: 8\u00a0months old). The lung sound parameters (the ratio of the third and fourth area to the total area under the curve [A<jats:sub>3<\/jats:sub>\/A<jats:sub>T<\/jats:sub> and B<jats:sub>4<\/jats:sub>\/A<jats:sub>T<\/jats:sub>], and the ratio of power and frequency at 50% and 75% of the highest frequency [RPF<jats:sub>50<\/jats:sub> and RPF<jats:sub>75<\/jats:sub>]) were evaluated at the first visit. At 3\u2009years old, using a questionnaire, we examined the relationship between the lung sound parameters and risk factors of asthma development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 268 infants, 175 infants were in good health and 93 had a history of acute respiratory infection (ARI) within 7\u2009days at the first visit. Among the 3\u2010 to 12\u2010month\u2010old infants with an ARI, the A<jats:sub>3<\/jats:sub>\/A<jats:sub>T<\/jats:sub>, B<jats:sub>4<\/jats:sub>\/A<jats:sub>T<\/jats:sub> values in those with a history of asthma\/asthmatic bronchitis, atopic dermatitis, and atopy were smaller than in the infants without such histories. Among the 13\u2010 to 24\u2010month\u2010old infants with an ARI, the A<jats:sub>3<\/jats:sub>\/A<jats:sub>T<\/jats:sub> and B<jats:sub>4<\/jats:sub>\/A<jats:sub>T<\/jats:sub> values in those with a wheezing history were larger than in the infants without such a history.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The characteristics of the lung sounds in infants with risk factors for asthma development were demonstrated over long\u2010term follow\u2010up. Lung sound analyses may be useful for assessing the airway condition of infants.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.379","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T17:56:03Z","timestamp":1631901363000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Lung sound analysis in infants with risk factors for asthma development"],"prefix":"10.1002","volume":"4","author":[{"given":"Manabu","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Department of Pediatrics Dokkyo Medical University  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigemi","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Dokkyo Medical University  Mibu Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1489-7691","authenticated-orcid":false,"given":"Hiromi","family":"Shioya","sequence":"additional","affiliation":[{"name":"Division of Pediatrics National Hospital Organization Yokohama Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Tadaki","sequence":"additional","affiliation":[{"name":"Division of Pediatrics National Hospital Organization Yokohama Medical Center  Yokohama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomohiko","family":"Imamura","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Enseki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Koike","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Furuya","sequence":"additional","affiliation":[{"name":"Department of Basic Clinical Science and Public Health Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1520-0393","authenticated-orcid":false,"given":"Hiroyuki","family":"Mochizuki","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Tokai University School of Medicine  Isehara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"e_1_2_13_2_1","unstructured":"Global Initiative for Asthma. Global Strategy for Asthma Management and Prevention.http:\/\/ginasthma.org\/wp-content\/uploads\/2020\/04\/GINA-2020. Accessed December 9 2020."},{"volume-title":"Guidelines for the Treatment and Management of Pediatric Bronchial Asthma 2020 (Japanese)","year":"2020","author":"Japanese Society of Pediatric Allergy and Clinical Immunology","key":"e_1_2_13_3_1"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197302012880501"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200504-525OC"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.01.034"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.88.3.364"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/141.5_Pt_1.1147"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/2319-4170.137773"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2015.07.002"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2016.02.001"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13177"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2018.05.004"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2016.11.005"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2018.07.011"},{"issue":"4","key":"e_1_2_13_16_1","first-page":"195","article-title":"New technique to analyze the breath sound spectrum in children with asthma","volume":"45","author":"Koike H","year":"2020","journal-title":"Tokai J Exp Clin Med"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/ped.2019.1131"},{"issue":"6","key":"e_1_2_13_18_1","first-page":"1","article-title":"Epidemiology Standardization Project (American Thoracic Society)","volume":"118","author":"Ferris BG","year":"1978","journal-title":"Am Rev Respir Dis"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1990.69.6.2126"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.100.4.999"},{"issue":"2","key":"e_1_2_13_21_1","first-page":"481","article-title":"Measurement and theory of wheezing breath sounds","volume":"57","author":"Gavriely N","year":"1984","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.2196\/24587"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-019-03363-2"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01523-9"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00431-019-03565-8"},{"issue":"2","key":"e_1_2_13_26_1","first-page":"74","article-title":"Clinical application of high\u2010pitched breath sound in children with asthma","volume":"43","author":"Kondo Y","year":"2018","journal-title":"Tokai J Exp Clin Med"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501193320301"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(98)10321-5"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201609-1812OC"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.12-RAI-0440"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202001-0194OC"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.379","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.379","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T08:18:20Z","timestamp":1693297100000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/hsr2.379"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.379","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"type":"print","value":"2398-8835"},{"type":"electronic","value":"2398-8835"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"2021-04-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-08-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e379"}}