{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:18:14Z","timestamp":1788347894390,"version":"build-2803163510"},"reference-count":25,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T00:00:00Z","timestamp":1634169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study aims at evaluating whether subjective donor deferral (SDD) has the potential for increasing blood transfusion safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Background<\/jats:title><jats:p>Appropriate donor selection via clinical and serologic screening is necessary to prevent transfusion\u2010transmissible infections (TTIs). One additional strategy adopted by some Brazilian blood transfusion centers (BTCs) is the rejection of a donation by the pre\u2010donation interviewer based on subjective factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods\/Materials<\/jats:title><jats:p>We conducted a STROBE\u2010guided cross\u2010sectional study including 105\u2009005 prospective donors who presented to our BTC between 1 January 2013, and 31 December 2015. Donors were evaluated for age, gender, education level, donation type and history, confidential unit exclusion, SDD, and results of serologic screening for TTIs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Even after controlling for potential confounding variables, subjectively deferred donors were more likely to have at least one reactive serology in the standard screening (OR: 2.80; 95% CI: 2.13\u20103.69; <jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.001). They also had a higher risk for testing positive for syphilis (OR: 4.47; 95% CI: 3.05\u20106.55; <jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.001), hepatitis B (OR: 5.69; 95% CI: 2.48\u201013.08; <jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.001), and HIV (OR: 6.14; 95% CI: 3.22\u201011.69; <jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Routine implementation of SDD in donor selection may be an effective additional measure to avoid TTIs, highlighting the importance of interviewer experience, perspicacity, and face\u2010to\u2010face contact with donors for blood safety assurance.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.424","type":"journal-article","created":{"date-parts":[[2021,10,19]],"date-time":"2021-10-19T16:19:09Z","timestamp":1634660349000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Subjective donor deferral as a tool for increased blood transfusion safety: A cross\u2010sectional observational study"],"prefix":"10.1002","volume":"4","author":[{"given":"Juliane Gir\u00e3o","family":"de Moura","sequence":"first","affiliation":[{"name":"Department of Hematology Center of Hematology and Hemotherapy of Cear\u00e1 (HEMOCE)  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1816-4498","authenticated-orcid":false,"given":"Bruno Almeida","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Medicine, Icahn School of Medicine at Mount Sinai Mount Sinai Morningside and Mount Sinai West  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana Aguiar Carneiro","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Hematology Center of Hematology and Hemotherapy of Cear\u00e1 (HEMOCE)  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Vagnaldo","family":"Fechine","sequence":"additional","affiliation":[{"name":"Clinical Pharmacology Unit, Drug Research and Development Center (NPDM) Federal University of Cear\u00e1 (UFC)  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00canio Simas","family":"Macedo","sequence":"additional","affiliation":[{"name":"Walter Cantidio Teaching Hospital (HUWC) Federal University of Cear\u00e1 (UFC)  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Lucio Jorge","family":"Barbosa","sequence":"additional","affiliation":[{"name":"Department of Hematology Center of Hematology and Hemotherapy of Cear\u00e1 (HEMOCE)  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franklin Jos\u00e9 Candido","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Hematology Center of Hematology and Hemotherapy of Cear\u00e1 (HEMOCE)  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"de Francesco Daher","sequence":"additional","affiliation":[{"name":"Walter Cantidio Teaching Hospital (HUWC) Federal University of Cear\u00e1 (UFC)  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Maria","family":"de Barros Carlos","sequence":"additional","affiliation":[{"name":"Department of Hematology Center of Hematology and Hemotherapy of Cear\u00e1 (HEMOCE)  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise Menezes","family":"Brunetta","sequence":"additional","affiliation":[{"name":"Department of Hematology Center of Hematology and Hemotherapy of Cear\u00e1 (HEMOCE)  Fortaleza Brazil"},{"name":"Walter Cantidio Teaching Hospital (HUWC) Federal University of Cear\u00e1 (UFC)  Fortaleza Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,14]]},"reference":[{"key":"e_1_2_12_2_1","volume-title":"Coordena\u00e7\u00e3o Nacional de Doen\u00e7as Sexualmente Transmiss\u00edveis e Aids. 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