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The effects of ARCC on wound healing in adult and aged mice were comparatively evaluated through a full\u2010thickness skin defect model. In addition, we randomly selected 10 patients aged 55 to 70 years from a cohort of 500 patients with diabetic feet to assess their prognosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>As the results showed that the healing rate had delayed in aged mice compared to adult mice, while ARCC prominently augmented the healing process in aged mice. Moreover, ARCC treatment wounds in aged mice showed accelerated re\u2010epithelization, enhanced granulation tissue formation, and increased vascularization, which was similar to that of adult mice. Furthermore, ARCC also achieved therapeutic effects in diabetic foot patients, accelerating wound healing. The results found that foot ulcers improved significantly 7\u2009days after the ARCC administration, and 80% of patients were healed within 1\u00a0month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In the present study, ARCC was found to have therapeutic effects on both acute and chronic wounds in animal models. ARCC also demonstrated therapeutic effects in diabetic feet, which promoted wound healing, prevented wound infection, and avoided the risk of further surgery or amputation. All these evidences suggested ARCC was a promising approach for wound treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>ARCC might be recommended as a promising therapeutic medication in diabetic and chronic refractory wounds.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.494","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T04:24:43Z","timestamp":1650515083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Promotive effects of four herbal medicine <scp>ARCC<\/scp> on wound healing in mice and human"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9085-5659","authenticated-orcid":false,"given":"Lingzhi","family":"Zhong","sequence":"first","affiliation":[{"name":"Department of Tissue Repair and Regeneration The First Medical Center, Chinese PLA General Hospital  Beijing China"},{"name":"Research Center for 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