{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T17:08:09Z","timestamp":1763831289913,"version":"3.44.0"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T00:00:00Z","timestamp":1646784000000},"content-version":"vor","delay-in-days":8,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Uterine fibroid is a common benign pelvic tumor and abdominal myomectomy may cause excessive intraoperative bleeding, which may lead to adverse outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study was planned to evaluate the effectiveness of the injection of lidocaine plus epinephrine to reduce intraoperative bleeding in abdominal myomectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>During October 2019 and May 2020, 60 eligible women with uterine fibroids were enrolled in a randomized controlled trial. Our patients were divided into two groups of lidocaine plus epinephrine defined as Group L and placebo defined as Group P. In group L, lidocaine 3 mg\/kg plus 0.5 ml of adrenaline which reached to 50 cc with saline solution and in group P, 50 ml of normal saline was used. Both the combined solution and normal saline were infiltrated to the serous and myometrium above and around the fibroid before incision. Patients' demographic data, total operative time, hemoglobin changes, and the degree of surgical difficulty\u00a0were evaluated and compared between the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was no significant difference between the two groups in terms of demographic data. Hemoglobin changes (<jats:italic>p<\/jats:italic>\u2009\u20090.0001) and the degree of surgery difficulty (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) were significantly lower in Group L compared with Group P. In each group the drop in hemoglobin levels from baseline to 4\u2009h postoperatively was significant (<jats:italic>p<\/jats:italic>\u2009\u20090.0001). A significantly meaningful correlation was reported between hemoglobin changes and the degree of surgery difficulty with the size of the uterine and fibroids (<jats:italic>p\u2009<\/jats:italic>&lt;\u20090.05). While a negative correlation was found regarding gravidity and surgery difficulty (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.413, <jats:italic>p<\/jats:italic>\u2009=\u20090.02). Surgery duration was longer in Group P compared with Group L 70.66\u2009\u00b1\u200919.85 versus 66.16\u2009\u00b1\u200914.48, respectively, but with no significant difference (<jats:italic>p<\/jats:italic>\u2009=\u20090.32). No significant adverse reaction or serious complication was reported in the two groups. Hemodynamic parameters were kept in the normal range throughout the surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A combination of lidocaine plus epinephrine during abdominal myomectomy appears to be a safe and effective method in reducing blood loss.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.551","type":"journal-article","created":{"date-parts":[[2022,3,9]],"date-time":"2022-03-09T05:48:45Z","timestamp":1646804925000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Safety and efficacy of lidocaine plus epinephrine on intraoperative bleeding in abdominal myomectomy: A double\u2010blind clinical trial"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1503-3502","authenticated-orcid":false,"given":"Mandana","family":"Mansour\u2010Ghanaei","sequence":"first","affiliation":[{"name":"Reproductive Health Research Center, Department of Obstetrics &amp; Gynecology, Al\u2010zahra Hospital, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8871-4483","authenticated-orcid":false,"given":"Fatemeh","family":"Hosseinzadeh","sequence":"additional","affiliation":[{"name":"Reproductive Health Research Center, Department of Obstetrics &amp; Gynecology, Al\u2010zahra Hospital, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7815-3769","authenticated-orcid":false,"given":"Seyedeh Hajar","family":"Sharami","sequence":"additional","affiliation":[{"name":"Reproductive Health Research Center, Department of Obstetrics &amp; Gynecology, Al\u2010zahra Hospital, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1716-1324","authenticated-orcid":false,"given":"Gelareh","family":"Biazar","sequence":"additional","affiliation":[{"name":"Anesthesiology Research Center, Department of Anesthesiology, Al\u2010zahra hospital Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-5675","authenticated-orcid":false,"given":"Fatemeh","family":"Noori","sequence":"additional","affiliation":[{"name":"Reproductive Health Research Center, Department of Obstetrics &amp; Gynecology, Al\u2010zahra Hospital, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6464-197X","authenticated-orcid":false,"given":"Seyed Mohammad","family":"Asgari\u2010Ghalebin","sequence":"additional","affiliation":[{"name":"School of 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