{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T20:17:21Z","timestamp":1791404241564,"version":"4.3.3"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Sputum neutrophil elastase (NE) is a marker of neutrophilic airway inflammation in bronchiectasis. Yet, not much is known about its role in pediatric bronchiectasis severity. This study aimed to assess the sputum NE value as a biomarker of clinical and radiological severity in pediatric bronchiectasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a cross\u2010sectional study assessing sputum NE in a total of 50 bronchiectasis patients under the age of 18 years\u201430 patients with cystic fibrosis (CF) and 20 patients with non\u2010CF bronchiectasis were included. Bronchiectasis severity was assessed using Shwachman\u2013Kulczycki (SK) score, CF\u2010ABLE score, and CF risk of disease progression score, among CF patients, and bronchiectasis severity index (BSI) and\u00a0FACED\u00a0criteria among non\u2010CF bronchiectasis patients, associations between\u00a0sputum NE and bronchiectasis severity were assessed in both patient groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sputum NE was directly correlated with C\u2010reactive protein (<jats:italic>r<\/jats:italic>\u2009=\u20090.914, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), (<jats:italic>r<\/jats:italic>\u2009=\u20090.786, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), frequency of exacerbations (<jats:italic>r<\/jats:italic>\u2009=\u20090.852, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) (<jats:italic>r<\/jats:italic>\u2009=\u20090.858, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), exacerbations severity (<jats:italic>r<\/jats:italic>\u2009=\u20090.735, <jats:italic>p<\/jats:italic>\u2009=\u20090.002), (<jats:italic>r<\/jats:italic>\u2009=\u20090.907, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and the number of hospital admissions (<jats:italic>r<\/jats:italic>\u2009=\u20090.813, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), (<jats:italic>r<\/jats:italic>\u2009=\u20090.612, <jats:italic>p \u2009=<\/jats:italic>0.004) in the last year among CF, and non\u2010CF bronchiectasis patients, respectively. Additional linear correlations were found between sputum NE, CF risk of disease progression score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), CF\u2010ABLE score (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and lower forced expiratory volume 1% of predicted (<jats:italic>p\u2009<\/jats:italic>=\u20090.017; <jats:italic>\u03c1<\/jats:italic>\u2009=\u2009\u22120.8) among CF patients. Moreover, sputum NE was positively correlated with the neutrophil count (<jats:italic>p<\/jats:italic>\u2009=\u20090.018), and BSI severity score (<jats:italic>p<\/jats:italic> = 0.039; <jats:italic>\u03c1<\/jats:italic>\u2009=\u20090.465) among non\u2010CF bronchiectasis patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sputum NE may be considered a good biomarker of bronchiectasis severity in both CF and non\u2010CF bronchiectasis patients, as confirmed by the exacerbations rate, CF risk of disease progression, and BSI scores.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.581","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T16:05:41Z","timestamp":1650470741000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sputum neutrophil elastase and its relation to pediatric bronchiectasis severity: A cross\u2010sectional study"],"prefix":"10.1002","volume":"5","author":[{"given":"Heba A.","family":"Ali","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Pulmonology Division, Faculty of Medicine Ain Shams University Children's Hospital  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman M.","family":"Fouda","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pulmonology Division, Faculty of Medicine Ain Shams University Children's Hospital  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona A.","family":"Salem","sequence":"additional","affiliation":[{"name":"Department of Radiology Ain Shams University Hospital  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa A.","family":"Abdelwahad","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Ain Shams University Hospital  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heba H.","family":"Radwan","sequence":"additional","affiliation":[{"name":"Ministry of Health  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,4,20]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00119114"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.5409\/wjcp.v6.i3.132"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/642503"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-017-0691-x"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198007033030109"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200605-632OC"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb\/4.1.26"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-1993(11)60009-X"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.5694\/mja14.00287"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.26719\/2012.18.9.962"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.05.00034805"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201309-1575OC"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/09031936.00026313"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1958.02060060008002"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2019.11.22"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.12-2022"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.60.03.009"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199409083311003"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2010.136119"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201605-1027OC"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0507OC"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.06.001"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(18)30171-1"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-01-0060"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-010-1056-4"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1301725"},{"issue":"4","key":"e_1_2_13_28_1","first-page":"1075","article-title":"Early pulmonary inflammation in infants with cystic fibrosis","volume":"151","author":"Khan TZ","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200901-0069OC"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.117.2.420"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201203-0487OC"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.20165"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/153.5.902"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/148.6_Pt_1.1665"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200609-1354OC"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12219"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.12582"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1513\/AnnalsATS.201411-513OC"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.581","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/hsr2.581","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.581","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T23:58:15Z","timestamp":1692316695000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,20]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1002\/hsr2.581"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.581","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,4,20]]},"assertion":[{"value":"2021-08-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e581"}}