{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T17:55:08Z","timestamp":1758477308077,"version":"3.41.2"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T00:00:00Z","timestamp":1651536000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Early biventricular dysfunction in repaired tetralogy of Fallot (TOF) children may lead to poor clinical outcomes. We aimed to assess biventricular function in TOF children before and after surgery by speckle tracking echocardiography (STE) and compare them with the controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty repaired TOF children and 20 normal children as controls were assessed by STE. Tricuspid annular plane systolic excursion (TAPSE), left ventricular ejection fraction (LVEF), biventricular strain, and strain rate were compared before and after surgery and between TOF children and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Postoperative LVEF (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), strain (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), and strain rate (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) for left ventricle improved significantly compared to preoperative phase. However, postoperative left ventricular strain (<jats:italic>p<\/jats:italic>\u2009=\u20090.05) and strain rate (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) in TOF children were significantly impaired compared to controls. Postoperative LVEF was correlated inversely with postoperative strain rate (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.40, <jats:italic>p<\/jats:italic>\u2009=\u20090.04). Postoperative TAPSE (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), strain (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), and strain rate (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) for right ventricle significantly worsened when compared with the preoperative phase. Moreover, postoperative TAPSE (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), strain (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), and strain rate (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) were significantly impaired compared to controls. Postoperative right ventricular strain rate was correlated significantly with the weight of children (<jats:italic>r<\/jats:italic>\u2009=\u20090.48, <jats:italic>p<\/jats:italic>\u2009=\u20090.02), and postoperative left ventricular strain showed significant correlations with aortic clamp time (<jats:italic>r<\/jats:italic>\u2009=\u20090.44, <jats:italic>p<\/jats:italic>\u2009=\u20090.04) and with ICU stay (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.46, <jats:italic>p<\/jats:italic>\u2009=\u20090.04).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite normal LVEF, TOF children exhibit impaired left ventricular strain and strain rate after surgery. TAPSE, strain, and strain rate for the right ventricle worsen after surgical repair. STE\u2010driven strain can be used to detect early ventricular dysfunction and the associated prognostic implications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.613","type":"journal-article","created":{"date-parts":[[2022,5,3]],"date-time":"2022-05-03T11:18:26Z","timestamp":1651576706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biventricular strain and strain rate impairment shortly after surgical repair of tetralogy of Fallot in children: A case\u2010control study"],"prefix":"10.1002","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3684-8196","authenticated-orcid":false,"given":"Bahar","family":"Dehghan","sequence":"first","affiliation":[{"name":"Pediatric Cardiovascular Research Center, Cardiovascular Research Institute Isfahan University of Medical Sciences Isfahan 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