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This study seeks to thoroughly grasp the epidemiology and transmission patterns of CCHF, which is caused by the CCHF virus (CCHFV), a member of the Nairovirus genus in the Bunyaviridae family.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The study investigates the global distribution and endemicity of CCHF, its mortality rates, modes of transmission (including tick bites, contact with infected animal blood, and limited person\u2010to\u2010person transmission), and factors influencing its prevalence across different regions. Genetic diversity within CCHFV and its impact on transmission dynamics are explored, along with efforts to control the disease through tick prevention, antiviral treatment, and the development of vaccines and diagnostics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CCHFV exhibits widespread distribution, particularly in the Middle East, Africa, Asia, and Eastern Europe, with an overall mortality rate of approximately 30% and a case fatality rate ranging from 10% to 40%. Transmission occurs primarily through tick bites and contact with infected animal blood, with limited person\u2010to\u2010person transmission. Livestock workers, slaughterhouse employees, and animal herders in endemic areas are most affected by their frequent interaction with sick animals and ticks. Genetic diversity within CCHFV contributes to variations in transmission dynamics, complicating control efforts. Antiviral ribavirin shows efficacy in treating CCHF infection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study underscores the importance of further research to understand the enzootic environment, transmission routes, and genetic diversity of CCHFV for effective control measures, including the development of vaccines, treatment options, and diagnostics.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70053","type":"journal-article","created":{"date-parts":[[2024,9,3]],"date-time":"2024-09-03T04:34:55Z","timestamp":1725338095000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Control strategies for emerging infectious diseases: Crimean\u2010Congo hemorrhagic fever management"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3738-4381","authenticated-orcid":false,"given":"Shriyansh","family":"Srivastava","sequence":"first","affiliation":[{"name":"Department of Pharmacology Delhi Pharmaceutical Sciences and Research University (DPSRU) Sector 3 Pushp Vihar New Delhi India"},{"name":"Department of Pharmacy, School of Medical and Allied Sciences Galgotias University Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachin","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Delhi Pharmaceutical Sciences and Research University (DPSRU) Sector 3 Pushp Vihar New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pramod Kumar","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, School of Medical and Allied Sciences Galgotias University Greater Noida India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarvesh","family":"Rustagi","sequence":"additional","affiliation":[{"name":"School of Applied and Life Sciences Uttaranchal University Dehradun Uttarakhand India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aroop","family":"Mohanty","sequence":"additional","affiliation":[{"name":"Department of Microbiology All India Institute of Medical Sciences Gorakhpur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne","family":"Donovan","sequence":"additional","affiliation":[{"name":"Department of Medicine David Geffen School of Medicine at UCLA Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres F.","family":"Henao\u2010Martinez","sequence":"additional","affiliation":[{"name":"Division of Infectious Diseases University of Colorado Anschutz Medical Campus Aurora Coloardo USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit","family":"Sah","sequence":"additional","affiliation":[{"name":"Department of Microbiology Tribhuvan University Teaching Hospital, Institute of Medicine Kathmandu Nepal"},{"name":"Department of Microbiology Dr. D. 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