{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T14:51:18Z","timestamp":1783003878378,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T00:00:00Z","timestamp":1727049600000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Due to the adverse effects of their disease, patients with thalassemia major face many problems such as a lack of proper growth, enlarged spleen and liver, bone disorders, especially the bones of the head and face. As a result of the long treatment process of this disease, other aspects of their life are also affected. The physical and mental problems in this population of patients will lead to frustration and lower social performance and quality of life. The present study aimed to explore the effect of an educational intervention based on the PRECEDE model on quality of life of adults with thalassemia major in Hormozgan province.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The present quasi\u2010experimental study was conducted on 234 adults with major thalassemia who visited the thalassemia medical centers in Hormozgan province in 2022. The participants were selected through a simple randomization from two cities of Hormozgan province (Bandar Abbas as the intervention group and Minab as the control). Each group had an equal number of participants (<jats:italic>n<\/jats:italic>\u2009=\u2009117). The data were collected using a demographic information questionnaire, a researcher\u2010made questionnaire based on the model constructs and the SF\u201012 quality of life questionnaire. The instruments were once administered before the intervention and once again 4 months after the intervention. The educational intervention included 3 sessions a week, each 60\u2009min in length, shared in WhatsApp and Telegram. The data were analyzed in statistical package for the social sciences version 24 using Mann\u2212Whitney <jats:italic>U<\/jats:italic>\u2010test, chi\u2010square test, Wilcoxon's test, and analysis of covariance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Findings<\/jats:title><jats:p>The results showed that after the educational intervention, the mean scores of knowledge, attitude, self\u2010efficacy, enabling afctors, reinforcing factors and the mean score of overall quality of life increased significantly in the intervention group compared to the control (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The covariance analysis showed when the effect of the pretest score is removed, the mean scores of the model constructs and the quality of life are significantly different in the two groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Educational interventions based on the PRECEDE model can help identify factors affecting the quality of life on many aspects in patients with thalassemia major. Thus, these interventions help improve patients' quality of life. The present findings can guide health policy makers and experts use modern educational interventions to develop the educational content to promote a healthy lifestyle and self\u2010management in certain diseases such as thalassemia major.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70075","type":"journal-article","created":{"date-parts":[[2024,9,24]],"date-time":"2024-09-24T05:49:01Z","timestamp":1727156941000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness of educational intervention on quality of life in adults with thalassemia major: A quasi\u2010experimental study based on PRECEDE model"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8446-0992","authenticated-orcid":false,"given":"Laleh","family":"Hassani","sequence":"first","affiliation":[{"name":"Social Determinants in Health Promotion Research Center, Hormozgan Health Research Institute Hormozgan University of Medical Sciences BandarAbbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5079-8223","authenticated-orcid":false,"given":"Niloofar","family":"Seyrafi","sequence":"additional","affiliation":[{"name":"Faculty of Health Hormozgan University of Medical Sciences BandarAbbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3716-243X","authenticated-orcid":false,"given":"Sama","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Faculty of Health Hormozgan University of Medical Sciences BandarAbbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2504-8014","authenticated-orcid":false,"given":"Teamur","family":"Aghamolaei","sequence":"additional","affiliation":[{"name":"Social Determinants in Health Promotion Research Center, Hormozgan Health Institute Hormozgan University of Medical Sciences BandarAbbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6623-4163","authenticated-orcid":false,"given":"Amin","family":"Ghanbarnejad","sequence":"additional","affiliation":[{"name":"Social Determinants in Health Promotion Research Center, Hormozgan Health Institute Hormozgan University of Medical Sciences BandarAbbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3645-7585","authenticated-orcid":false,"given":"Mohammad","family":"Reza Evazi","sequence":"additional","affiliation":[{"name":"School of Medicine Hormozgan University of Medical Sciences BandarAbbas Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,9,23]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05546.x"},{"issue":"1","key":"e_1_2_12_3_1","first-page":"186","article-title":"Quality of life of school age thalassemic children at Zagazig City","volume":"7","author":"Eldakhakhny AMM","year":"2011","journal-title":"J Amer Sci"},{"issue":"1","key":"e_1_2_12_4_1","first-page":"45","article-title":"Quality of life in children with thalassemia who referred to thalassemia center of Shafa Hospital","volume":"1","author":"Zarea K","year":"2012","journal-title":"Jundishapur J Chro Dis Care"},{"issue":"1","key":"e_1_2_12_5_1","first-page":"45","article-title":"Frequency of thalassemia in Iran and Khorasan Razavi","volume":"1","author":"Khodaei GH","year":"2013","journal-title":"Int J Pediatr"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/03630269.2019.1628774"},{"key":"e_1_2_12_7_1","unstructured":"Organization WH. 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