{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T18:29:30Z","timestamp":1787509770786,"version":"build-2736575974"},"reference-count":46,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,9,29]],"date-time":"2024-09-29T00:00:00Z","timestamp":1727568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      In malaria endemic regions,\n                      <jats:italic>Plasmodium falciparum<\/jats:italic>\n                      infection is characterized by variable genetic diversity at different settings. The parasite's various forms are found at varied frequency in different geographic areas. Understanding malaria parasite diversity and transmission is vital to evaluate control interventions. The aim of this study was under taken to determine the status of\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      genetic diversity and MOI in different regions of Ethiopia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Relevant publications were identified from electronic databases such as; PubMed, EMBASE, Google scholar and Google. Besides, an online search was done using the above databases for all articles published in English on genetic diversity of\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      in Ethiopia. STATA software was used for data analysis. The pooled estimates were calculated using random effect model. The summary estimates were presented using forest plots and tables.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 11 studies were included in the systematic review. However, only 8, 10 and 2 studies were included for Pfmsp\u20101, Pfmsp\u20102 and glurp gene meta\u2010analysis, respectively. However, the meta\u2010analysis result showed that the pooled prevalence of Pfmsp\u20101, msp\u20102 and glurp gene were 84% for both msp\u20101\/2% and 51%, respectively. The pooled prevalence of msp\u20101 gene was higher in Amhara followed by Oromia region and lower in SNNPR while, for msp\u20102 gene the pooled prevalence was higher in Benshangul gumez region. Among the allelic family of msp\u20101 and msp\u20102 genes, MAD20 (34%) and FC27 (44%) were the most predominant respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      Based on the review, there is evidence of the presence of high genetic diversity of\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      parasites in Ethiopia, suggesting that malaria transmission remain high and that strengthened control efforts are needed. The approaches and methods used for investigation of diversified parasites have similarity between studies and should use advanced molecular techniques, like microsatellite, to assess the genetic diversity of\n                      <jats:italic>P. falciparum<\/jats:italic>\n                      for better results.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70092","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T00:38:56Z","timestamp":1727656736000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["<i>Plasmodium falciparum<\/i>\n                    genetic diversity; implications for malaria control in Ethiopia: Systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-9220-1857","authenticated-orcid":false,"given":"Zufan 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