{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:51:14Z","timestamp":1790290274346,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,20]],"date-time":"2024-10-20T00:00:00Z","timestamp":1729382400000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Tuberculosis (TB) remains a major public health concern in Pakistan, which is ranked fifth among high\u2010burden TB nations worldwide. The growing frequency of drug\u2010resistant TB strains, particularly multidrug\u2010resistant TB (MDR\u2010TB), creates new obstacles. Socioeconomic factors, a lack of awareness, and inadequate healthcare infrastructure all contribute to the spread of the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigates the mechanisms contributing to the growth in tuberculosis cases in Pakistan, the implications for public health, and multifaceted approaches to prevention and control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature study was undertaken, including an analysis of peer\u2010reviewed articles, World Health Organization (WHO) data, and government sources, to identify factors driving tuberculosis prevalence, control issues, and disease\u2010fighting tactics.<\/jats:p><jats:p>Result: Several factors like Poverty, overcrowding, malnutrition, stigma, and restricted access to healthcare services are all factors contributing to an increase in tuberculosis incidence in Pakistan. The prevalence of MDR\u2010TB, along with a lack of an integrated healthcare response, complicates efforts to contain the disease's spread. Tuberculosis has a profound social, mental, and financial impact on individuals and communities. Public health efforts, such as the National Tuberculosis Control Program (NTP) and international partnerships, have been created to eradicate tuberculosis, although considerable hurdles persist.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study investigates the mechanisms contributing to the growth in tuberculosis cases in Pakistan, the implications for public health, and multifaceted approaches to prevention and control.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70130","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T06:09:34Z","timestamp":1729490974000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The rising tide of tuberculosis in Pakistan: Factors, impact, and multi\u2010faceted approaches for prevention and control"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2166-0887","authenticated-orcid":false,"given":"Hamid","family":"Ullah","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Dow Medical College Dow University of Health and Sciences Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3056-7628","authenticated-orcid":false,"given":"Hafsa","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dow Medical College Dow University of Health and Sciences Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3575-7674","authenticated-orcid":false,"given":"Ariba","family":"Salman","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dow Medical College Dow University of Health and Sciences Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5117-5128","authenticated-orcid":false,"given":"Rabia","family":"Iqbal","sequence":"additional","affiliation":[{"name":"Faculty of Medical Technology Dow University of Health Sciences Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4003-0437","authenticated-orcid":false,"given":"Sayed Jawad","family":"Hussaini","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Dow Medical College Dow University of Health and Sciences Karachi Pakistan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9440-4393","authenticated-orcid":false,"given":"Abdullah","family":"Malikzai","sequence":"additional","affiliation":[{"name":"Kabul University of Medical Sciences Kabul Afghanistan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,20]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"emhj. 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