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As a result, there has been advances in defining genetic variants responsible for different responses to cardiovascular drugs such as antiplatelets, anticoagulants, statins, and beta\u2010blockers, which has led to their usage in guiding treatment plans. This study comprehensively reviews the current state\u2010of\u2010the\u2010art potential of pharmacogenomics in dramatically altering CVD treatment. It stresses the applicability of pharmacogenomic technology, the threats associated with its adoption in the clinical setting, and proffers relevant solutions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature search strategies were used to retrieve articles from various databases: PubMed, Google Scholar, and EBSCOhost. Articles with information relevant to pharmacogenomics, DNA variants, cardiovascular diseases, sequencing techniques, and drug responses were reviewed and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>DNA\u2010based technologies such as next generation sequencing, whole genome sequencing, whole exome sequencing, and targeted segment sequencing can identify variants in the human genome. This has played a substantial role in identifying different genetic variants governing the poor response and adverse effects associated with cardiovascular drugs. Thus, this has reduced patients' number of emergency visits and hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Despite the emergence of pharmacogenomics, its implementation has been threatened by factors including patient compliance and a low adoption rate by clinicians. Education and training programs targeting both healthcare professionals and patients should be established to increase the acceptance and application of the emerging pharmacogenomic technologies in reducing the burden of CVDs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70139","type":"journal-article","created":{"date-parts":[[2024,10,21]],"date-time":"2024-10-21T06:23:31Z","timestamp":1729491811000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Pharmacogenomics revolutionizing cardiovascular therapeutics: A narrative review"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9086-1135","authenticated-orcid":false,"given":"Samuel","family":"Inshutiyimana","sequence":"first","affiliation":[{"name":"Department of Research and Education Oli Health Magazine Organization Kigali Rwanda"},{"name":"Department of Pharmaceutics and Pharmacy Practice, School of Pharmacy and Health Sciences United States International University\u2010Africa Nairobi Kenya"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6382-0538","authenticated-orcid":false,"given":"Nagham","family":"Ramadan","sequence":"additional","affiliation":[{"name":"Department of Research and Education Oli Health Magazine Organization Kigali Rwanda"},{"name":"Department of Medicine, Faculty of Medicine Beirut Arab University Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5124-8346","authenticated-orcid":false,"given":"Rawane Abdul","family":"Razzak","sequence":"additional","affiliation":[{"name":"Department of Research and Education Oli Health Magazine Organization Kigali Rwanda"},{"name":"Faculty of Medical Sciences Lebanese University Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7095-7842","authenticated-orcid":false,"given":"Zeina","family":"Al Maaz","sequence":"additional","affiliation":[{"name":"Department of Research and Education Oli Health Magazine Organization Kigali Rwanda"},{"name":"Department of Medicine, Faculty of Medicine Beirut Arab University (BAU) Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6903-0206","authenticated-orcid":false,"given":"Magda","family":"Wojtara","sequence":"additional","affiliation":[{"name":"Department of Research and Education Oli Health Magazine Organization Kigali Rwanda"},{"name":"Department of Human Genetics University of Michigan Medical School Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0692-9027","authenticated-orcid":false,"given":"Olivier","family":"Uwishema","sequence":"additional","affiliation":[{"name":"Department of Research and Education Oli Health Magazine Organization Kigali Rwanda"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,20]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"Cardiovascular Diseases (CVDs)","author":"WHO","year":"2021"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2016.09.040"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/HEARTVIEWS.HEARTVIEWS_106_17"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12051799"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.007252"},{"key":"e_1_2_9_7_1","unstructured":"WolvertonM. 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