{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:18:43Z","timestamp":1790115523449,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T00:00:00Z","timestamp":1731456000000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>This study aimed to evaluate the hemodynamic alterations and right heart remodeling dynamics in patients with inoperable chronic thromboembolic pulmonary hypertension (CTEPH) undergoing treatment with balloon pulmonary angioplasty (BPA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective cohort study involved a cohort of 31 patients with a confirmed diagnosis of CTEPH. Comprehensive clinical evaluations were systematically performed before BPA, and at 3 and 6 months following the procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant clinical progress was evidenced by the uplift in the percentage of patients achieving WHO\u2010FC II, escalating from 19.35% at baseline to 51.61% at 6 months after BPA (<jats:italic>p<\/jats:italic>\u2009=\u20090.003). NT\u2010proBNP levels significantly dropped from a median of 614.6 to 69.9\u2009pg\/mL\u00a0(<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Hemodynamic assessments showed significant decreases in mean PAP from 45.53\u2009\u00b1\u200911.19 to 22.56\u2009\u00b1\u20095.81\u2009mmHg (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and PVR from 8.33 to 2.86\u2009WU (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Echocardiographic analysis revealed substantial reductions in the right atrial area (RAA, from 20.29\u2009\u00b1\u20097.55 to 16.79\u2009\u00b1\u20094.82\u2009cm<jats:sup>2<\/jats:sup>, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and right ventricular internal diameter (RVID, from 4.13\u2009\u00b1\u20090.79 to 3.68\u2009\u00b1\u20090.59\u2009cm, <jats:italic>p<\/jats:italic>\u2009=\u20090.001) at the 3\u2010month interval post\u2010BPA. These improvements were sustained or even enhanced by the 6\u2010month mark, with RAA and RVID further diminishing (to 14.46\u2009\u00b1\u20093.78\u2009cm<jats:sup>2<\/jats:sup> and 3.29\u2009\u00b1\u20090.54\u2009cm, respectively; both <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The TAPSE\/PASP ratios showed progressive improvement from baseline (0.32\u2009\u00b1\u20090.13) to 3 months (0.42\u2009\u00b1\u20090.13) and continued to improve at 6 months following BPA (0.50\u2009\u00b1\u20090.11, <jats:italic>p<\/jats:italic>\u2009=\u20090.04 compared to 3 months post\u2010BPA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>BPA has significantly ameliorated clinical conditions, hemodynamic profiles, and initiated a continued reversal in right heart remodeling in patients with CTEPH.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70159","type":"journal-article","created":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T12:35:27Z","timestamp":1731501327000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Improvements in Hemodynamics and Right Heart Remodeling Following Balloon Pulmonary Angioplasty Treatment in Patients With Chronic Thromboembolic Pulmonary Hypertension: A Retrospective Study"],"prefix":"10.1002","volume":"7","author":[{"given":"Qi\u2010Le","family":"Shen","sequence":"first","affiliation":[{"name":"School of Medicine Tongji University Shanghai China"},{"name":"Department of Emergency, Shanghai Tongren Hospital Shanghai Jiaotong University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4309-8880","authenticated-orcid":false,"given":"Qin\u2010Hua","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Circulation Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui\u2010Ting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pulmonary Circulation Shanghai Pulmonary Hospital, Tongji University School of Medicine Shanghai 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