{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T22:14:33Z","timestamp":1781129673288,"version":"3.54.1"},"reference-count":19,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T00:00:00Z","timestamp":1732060800000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>The healing of diabetic foot ulcers (DFUs) can be hindered by the susceptibility of the surrounding intact skin to pro\u2010inflammatory proteases. A conditioned media, known as PTT\u20106<jats:sup>TM<\/jats:sup>, derived from mesenchymal stem cells found in the lining of red deer umbilical cords, has been formulated to protect the intact peri\u2010wound skin of DFUs. The aim is to evaluate the clinical effectiveness of PTT\u20106<jats:sup>TM<\/jats:sup> in managing peri\u2010wound intact skin in hard\u2010to\u2010heal DFUs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with DFUs that persisted for over 3 months were divided into two subgroups. The active wound group received standard\u2010of\u2010care treatment protocol followed by PTT\u20106<jats:sup>TM<\/jats:sup> application around the peri\u2010wound area, while the maintenance wound group applied PTT\u20106<jats:sup>TM<\/jats:sup> media over the healed wound site.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty cases were recorded, of which 22 (55%) were included in the active wound group. The majority were male (75%, <jats:italic>n<\/jats:italic>\u2009=\u200930) and vast majority had cardiovascular risk factors, including diabetes mellitus (100%, <jats:italic>n<\/jats:italic>\u2009=\u200940), hyperlipidemia (82.5%, <jats:italic>n<\/jats:italic>\u2009=\u200933), and hypertension (77.5%, <jats:italic>n<\/jats:italic>\u2009=\u200931). Most patients had forefoot wounds (80%, <jats:italic>n<\/jats:italic>\u2009=\u200932) on the plantar aspect (82.5%, <jats:italic>n<\/jats:italic>\u2009=\u200933). The patients in the active wound group had chronic DFUs for a mean of 218\u2009\u00b1\u2009201 days. Of those treated with PTT\u20106\u2122 media, 68.4% (<jats:italic>n<\/jats:italic>\u2009=\u200913) achieved complete wound healing within a mean duration of 69\u2009\u00b1\u200950 days. Additionally, most patients in the maintenance wound group remained ulcer\u2010free at 3 months (91.7%, <jats:italic>n<\/jats:italic>\u2009=\u200911) and 6 months (66.7%, <jats:italic>n<\/jats:italic>\u2009=\u20096).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study results suggest that PTT\u20106<jats:sup>TM<\/jats:sup> media may serve as an additional treatment modality for enhancing the microenvironment at the peri\u2010wound intact skin site. This could indirectly facilitate wound healing by preserving the integrity of the peri\u2010wound intact skin.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70211","type":"journal-article","created":{"date-parts":[[2024,11,20]],"date-time":"2024-11-20T09:14:25Z","timestamp":1732094065000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Addressing the Peri\u2010Wound Intact Skin of Hard\u2010To\u2010Heal Diabetic Foot Ulcers With Topical Red Deer Conditioned Media (PTT\u20106<sup>TM<\/sup>) Skin Conditioner: A Case Series on Clinical Efficacy"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5419-4408","authenticated-orcid":false,"given":"Kimberley","family":"Leow","sequence":"first","affiliation":[{"name":"Department of Podiatry Sengkang General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leon Timothy Charles","family":"Alvis","sequence":"additional","affiliation":[{"name":"Department of Podiatry Sengkang General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley Edmond Charles","family":"Yuen","sequence":"additional","affiliation":[{"name":"Department of Podiatry Sengkang General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leighton","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Podiatry Sengkang General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiqi","family":"Chiam","sequence":"additional","affiliation":[{"name":"Department of Podiatry Sengkang General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siti Nurfarahdillah Binte Abdul","family":"Razak","sequence":"additional","affiliation":[{"name":"Department of Podiatry Sengkang General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerard Benjamin","family":"Evans","sequence":"additional","affiliation":[{"name":"Department of Podiatry Sengkang General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth","family":"Koh","sequence":"additional","affiliation":[{"name":"Department of Podiatry Sengkang General Hospital  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivor Jiun","family":"Lim","sequence":"additional","affiliation":[{"name":"CellResearch Corporation Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toan Thang","family":"Phan","sequence":"additional","affiliation":[{"name":"CellResearch Corporation Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keng Lin","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Sengkang General Hospital Singapore Singapore"},{"name":"Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore"},{"name":"Musculoskeletal Sciences Academic Clinical Programme Duke\u2010NUS Medical School Singapore Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0309364614534296"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.3402\/dfa.v1i0.5438"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"49","article-title":"Osteomyelitis in the Diabetic Foot: What Lies Beneath","volume":"15","author":"Nube V.","year":"2007","journal-title":"Primary Intention: The Australian Journal of Wound Management"},{"key":"e_1_2_10_5_1","first-page":"307","article-title":"Evaluation of the Surgical Treatment of Diabetic Foot","volume":"11","author":"Denjali\u0107 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