{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:42:33Z","timestamp":1769550153504,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Femoral artery access is widely used despite recent increase in radial access for percutaneous coronary interventions (PCI). Femoral artery closure devices are used to shorten vascular closure time and reduce bleeding. We sought to examine sex\u2010based outcomes of femoral artery vascular closure devices (VCD) in patients undergoing PCI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We identified patients who had undergone PCI (<jats:italic>n<\/jats:italic>\u2009=\u200911,415) in the Indiana University Health Multicenter Cardiac Cath registry using femoral artery access. Clinical outcomes were compared between VCD and manual compression and analyzed according to sex. Patients with cardiogenic shock and left ventricular support devices were excluded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The use of any vascular closure device as compared to femoral artery manual compression was associated with a reduction in 72\u2010h bleeding events (adjusted odds ratio [OR]: 0.64; 95% confidence interval [CI]: 0.46\u20130.87). With manual compression, women had higher rates of 72\u2010h bleeding as compared to men (4.5% vs. 1.6%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Women demonstrated greater absolute risk reduction in 72\u2010h bleeding events with use of VCD as compared to men (2.8% vs. 0.8%, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). For women, VCD were associated with lower risk of access site bleeding (OR: 0.43; 95% CI: 0.24\u20130.8), hematoma (OR: 0.36; 95% CI: 0.2\u20130.63), and vascular complications (OR: 0.25, 95% CI: 0.09\u20130.72). Use of VCD was associated with lower risk of in\u2010hospital death (adjusted OR: 0.4; 95% CI: 0.28\u20130.58; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in multivariable regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Women derive more benefit from use of femoral artery VCD during PCI than men with greater reduction in bleeding rates, access site hematoma, and vascular complications.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70256","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T09:21:21Z","timestamp":1734600081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Sex on Outcomes With Femoral Artery Closure Devices Versus Manual Compression in Patients Undergoing Percutaneous Coronary Intervention"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7417-9547","authenticated-orcid":false,"given":"Wesley L.","family":"Anderson","sequence":"first","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asad J.","family":"Torabi","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian A.","family":"O'leary","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey A.","family":"Breall","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anjan K.","family":"Sinha","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziad A.","family":"Jaradat","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michelle C.","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle A.","family":"Frick","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrahim A.","family":"Romeh","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali F.","family":"Iqtidar","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"von der Lohe","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2110-607X","authenticated-orcid":false,"given":"Rolf P.","family":"Kreutz","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Cardiovascular Medicine Indiana University School of Medicine Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJ-D-17-00723"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcin.2011.02.011"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.112.000536"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.061527"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlc.2016.10.021"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.25630"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0116496"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.28341"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1591019921996100"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2004.06.048"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.2459\/JCM.0000000000000697"},{"key":"e_1_2_13_13_1","unstructured":"NCDR 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Accessed May 17 2022 https:\/\/www.ncdr.com\/WebNCDR\/docs\/default-source\/public-data-collection-documents\/cathpci_v4_codersdictionary_4-4.pdf?sfvrsn1\/4b84d368e_2."},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jscai.2022.100370"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(12)61804-X"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.109.860494"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2016.11.004"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCINTERVENTIONS.117.006074"},{"key":"e_1_2_13_19_1","article-title":"Relationship Between Femoral Vascular Closure Devices and Short\u2010Term Mortality From 271 845 Percutaneous Coronary Intervention Procedures Performed in the United Kingdom Between 2006 and 2011: A Propensity Score\u2013Corrected Analysis From the British Cardiovascular Intervention Society","volume":"9","author":"Farooq V.","year":"2016","journal-title":"Circulation: Cardiovascular Interventions"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.1169"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300083R"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.21216"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.08.010"},{"key":"e_1_2_13_24_1","first-page":"298","article-title":"Gender Differences in Carotid Artery Intima\u2010Media Thickness and Flow\u2010Mediated Dilatation in Young, Physically Active Adults","volume":"54","author":"Mazurek K.","year":"2014","journal-title":"Journal of Sports Medicine and Physical Fitness"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590500097549"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(16)32582-0"},{"key":"e_1_2_13_27_1","first-page":"247","article-title":"Impact of Gender on Femoral Access Complications Secondary to Application of a Collagen\u2010Based Vascular Closure Device","volume":"16","author":"Eggebrecht H.","year":"2004","journal-title":"Journal of Invasive Cardiology"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1540-8183.2006.00107.x"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccd.21353"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.4244\/EIJV10I2A31"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12165255"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1129729820966946"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00174-5"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0304(199604)37:4<367::AID-CCD5>3.0.CO;2-9"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9149(99)00882-6"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2023.06.425"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.70256","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T07:29:24Z","timestamp":1745566164000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.70256"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/hsr2.70256"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.70256","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-04-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70256"}}