{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:21:30Z","timestamp":1791256890493,"version":"4.1.0"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T00:00:00Z","timestamp":1734998400000},"content-version":"vor","delay-in-days":23,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2024,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background and Aims<\/jats:title>\n Seborrheic dermatitis (SD) is a chronic inflammatory skin condition that affects patients' quality of life. Emerging evidence suggests that vitamin and mineral deficiencies may contribute to its progression, although the exact etiology remains unclear.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n This case\u2010control study assessed the serum levels of vitamin D and zinc in SD patients compared to a healthy control group, with a focus on how these deficiencies relate to disease severity.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n A total of 71\u2009SD patients and 71 healthy controls participated, providing demographic data and blood samples. Disease severity was evaluated using the SEDASI scoring system. Serum vitamin D and zinc levels were measured using ELISA and photometric methods, respectively. Statistical analysis was performed using t\u2010tests and chi\u2010square tests in SPSS 24, with groups matched for demographic variables (\n p<\/jats:italic>\n \u2009>\u20090.05).\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Findings revealed no significant difference in vitamin D levels between SD patients and the control group (\n p<\/jats:italic>\n \u2009=\u20090.066). However, zinc levels were notably lower in the SD group (\n p<\/jats:italic>\n \u2009=\u20090.001). Additionally, vitamin D levels were inversely related to the severity of SD (\n p<\/jats:italic>\n \u2009=\u20090.022), while no correlation was found between zinc levels and disease severity (\n p<\/jats:italic>\n \u2009=\u20090.664).\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n Zinc deficiency appears to play a role in SD pathogenesis, while lower vitamin D levels are associated with increased disease severity. These findings highlight the need for further research into the potential therapeutic role of nutrient supplementation in managing SD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/hsr2.70283","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T05:29:21Z","timestamp":1735018161000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring the Impact of Vitamin D and Zinc Deficiencies on Seborrheic Dermatitis: A Comparative Study"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-8245-5055","authenticated-orcid":false,"given":"Amine","family":"Kashiri","sequence":"first","affiliation":[{"name":"Gorgan Faculty of Medicine Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negin","family":"Maghsoudloo","sequence":"additional","affiliation":[{"name":"Gorgan Faculty of Medicine Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,24]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14091"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S284671"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.15121"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266-022-00930-5"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3906\/sag-1906-72"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"7","article-title":"The Relationship of Serum Selenium, Zinc, and Copper Levels With Seborrheic Dermatitis: A Case\u2010Control Study","volume":"22","author":"Hajheydari Z.","year":"2019","journal-title":"Iranian Journal of Dermatology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2021.e06621"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.20230022"},{"key":"e_1_2_10_10_1","volume-title":"Mayo Clinic Gastroenterology and Hepatology Board Review","author":"Stephen H. C.","year":"2024"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.48782"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6623271"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6623271"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ddg.14683"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1346-8138.16578"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14006"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.13188\/2373-1044.1000019"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.52547\/ajcm.28.1.20"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.14748\/ssm.v45i1.345"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.12310"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.5455\/medscience.2023.08.120"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-2226"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.5114\/amsad.2016.65075"},{"key":"e_1_2_10_24_1","unstructured":"S.G\u00fcderandH.G\u00fcder Seboreik dermatitli hastalarda serum vitamin B12 ferritin ve vitamin D d\u00fczeyleri: Bir olgu\u2010kontrol \u00e7al\u0131\u015fmas\u0131 (2022)."},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.07.079"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.1993.tb02238.x"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40257-019-00484-0"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2021.06.900"},{"key":"e_1_2_10_29_1","volume-title":"Pathogenic Factors and Comorbidity in Seborrheic Dermatitis. Role of Vitamin D","author":"Dimitrova J.","year":"2017"},{"key":"e_1_2_10_30_1","article-title":"Evaluation of the Levels of Trace Elements in the Blood and Hair of Patients With Seborrheic Dermatitis","volume":"36","author":"Nazik H.","year":"2018","journal-title":"Trace Elements and Electrolytes"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.70283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T03:30:45Z","timestamp":1745551845000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.70283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/hsr2.70283"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.70283","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-06-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-24","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70283"}}