{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T03:34:52Z","timestamp":1793504092960,"version":"4.5.0"},"reference-count":58,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T00:00:00Z","timestamp":1737072000000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>Dengue is a mosquito\u2010borne viral disease that frequently causes seasonal outbreaks in Bangladesh, particularly during the monsoon months from June to September. Recent outbreaks have shown significant shifts in clinical manifestations, including changes in the timeframe and serotype mixing. This study focused on the clinical and hematological profiles of patients during the 2022 outbreak, which was notably severe.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      This quantitative cross\u2010sectional study at Dhaka Medical College and Hospital classified 67 dengue\u2010positive patients as having dengue fever (DF), dengue fever with warning signs (DFWS), and severe dengue (SD). Fisher's exact test, Pearson's chi\u2010squared test, and Wilcoxon rank\u2010sum test were conducted for statistical analysis using the R software (version 4.2), with significance established at\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Predominantly male patients (76%) aged 21\u221240 (63%) and middle\u2010class patients from Dhaka (57%) formed the majority. Most patients (45%) lacked a regular drainage system. Laboratory tests showed 63% NS1 antigen (nonspecific antigen 1) positivity, and 16% tested positive for both NS1 and IgM (Immunoglobulin M). Symptoms included headache (84%), retroorbital pain (51%), joint pain (75%), myalgia (72%), vomiting (75%), abdominal pain (69%), diarrhea (39%), and shock (48%). Thrombocytopenia was present in 61% of patients, with 79% showing elevated hematocrit (HCT) levels. Pedal edema, pleural effusion, and ascites were observed in DF and DFWS cases, while SD cases exhibited distinct HCT level variations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Accurate clinical and laboratory assessments are vital for the treatment and prediction of dengue outcomes in Bangladesh, given the severe manifestations of dengue shock syndrome (DSS). It is characterized by headache, muscle pain, thrombocytopenia, anemia, leukopenia, and potential neurological complications or mortality. Severe cases involve critical plasma leakage, leading to DSS with fluid accumulation, respiratory distress, and potential multiorgan involvement. Enhancing physician awareness regarding dengue case detection and management, along with routine dengue testing, are recommended for early diagnosis and improved patient outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70356","type":"journal-article","created":{"date-parts":[[2025,1,17]],"date-time":"2025-01-17T04:16:44Z","timestamp":1737087404000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical and Hematological Manifestation of Dengue Patients in 2022 Outbreak: A Tertiary Care Hospital\u2010Based Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9323-4997","authenticated-orcid":false,"given":"Md. Jubayer","family":"Hossain","sequence":"first","affiliation":[{"name":"Population Health Studies Division Center for Health Innovation, Research, Action, and Learning\u2013Bangladesh (CHIRAL Bangladesh) Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0149-4586","authenticated-orcid":false,"given":"Manisha","family":"Das","sequence":"additional","affiliation":[{"name":"Population Health Studies Division Center for Health Innovation, Research, Action, and Learning\u2013Bangladesh (CHIRAL Bangladesh) Dhaka Bangladesh"},{"name":"Dhaka Medical College and Hospital Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhibullah","family":"Shahjahan","sequence":"additional","affiliation":[{"name":"Population Health Studies Division Center for Health Innovation, Research, Action, and Learning\u2013Bangladesh (CHIRAL Bangladesh) Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Wahidul","family":"Islam","sequence":"additional","affiliation":[{"name":"Population Health Studies Division Center for Health Innovation, Research, Action, and Learning\u2013Bangladesh (CHIRAL Bangladesh) Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5168-2572","authenticated-orcid":false,"given":"Syeda Tasneem","family":"Towhid","sequence":"additional","affiliation":[{"name":"Department of Microbiology Jagannath University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,17]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/8898453"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12060"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.31729\/jnma.7675"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1413-86702007000400007"},{"key":"e_1_2_15_6_1","volume-title":"Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control","author":"World Health Organization, Special Programme for Research","year":"2009"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15020572"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2014.10.009"},{"key":"e_1_2_15_9_1","unstructured":"\u201cPAHO\/WHO Data: Dengue [Internet] \u201d November 18 2024 https:\/\/www3.paho.org\/data\/index.php\/en\/mnu-topics\/indicadores-dengue-en.html."},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2912.231472"},{"issue":"2","key":"e_1_2_15_11_1","first-page":"88","article-title":"Frequency and Clinical Presentation of Dengue Fever at Tertiary Care Hospital of Hyderabad\/Jamshoro","volume":"9","author":"Khan A. H.","year":"2010","journal-title":"Journal of the Liaquat University of Medical and Health Sciences"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmv.2245"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/tropicalmed7080180"},{"key":"e_1_2_15_14_1","unstructured":"\u201cDengue and Severe Dengue [Internet] \u201d May 5 2023 https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dengue-and-severe-dengue."},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.micro.62.081307.163005"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41182-023-00528-6"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32524-3"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/trstmh\/traa126"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid0807.010398"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.3329\/jom.v13i2.12751"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.3329\/jom.v10i1.1996"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(19)30541-9"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-021-06788-z"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008567"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijidoh.2023.100001"},{"key":"e_1_2_15_26_1","unstructured":"\u201cDGHS Health Bulletin [Internet] \u201d May 5 2023 https:\/\/old.dghs.gov.bd\/index.php\/en\/publications\/health-bulletin\/dghs-health-bulletin."},{"key":"e_1_2_15_27_1","unstructured":"\u201cRevised Guideline for Clinical Management of Dengue [Internet] \u201d January 31 2024 https:\/\/old.dghs.gov.bd\/index.php\/en\/home\/5431-revised-guideline-for-clinical-management-of-dengue."},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-3557-z"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12878-018-0116-1"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008349"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0249135"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crpvbd.2021.100063"},{"key":"e_1_2_15_33_1","first-page":"20","article-title":"Clinical Profile of Dengue Haemorrhagic Fever in Adults During 1996\u2010Outbreak in Delhi","volume":"22","author":"Sharma S.","year":"1998","journal-title":"Dengue Bulletin"},{"issue":"8","key":"e_1_2_15_34_1","article-title":"Clinical Presentation and Platelet Profile of Dengue Fever: A Retrospective Study","volume":"14","author":"Vijay J.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_15_35_1","unstructured":"\u201cThe Numbers Behind Bangladesh's Goal of Middle Income Status by 2021 [Internet] \u201d January 31 2024 https:\/\/blogs.worldbank.org\/endpovertyinsouthasia\/numbers-behind-bangladesh's-goal-middle-income-status-2021."},{"key":"e_1_2_15_36_1","unstructured":"\u201cThe Numbers Behind Bangladesh's Goal of Middle Income Status by 2021 \u201d World Bank Blogs [Internet] November 19 2024 https:\/\/blogs.worldbank.org\/en\/endpovertyinsouthasia\/numbers-behind-bangladesh-s-goal-middle-income-status-2021."},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1086\/343813"},{"issue":"1","key":"e_1_2_15_38_1","first-page":"5","article-title":"Laboratory Diagnosis of Dengue Virus Infection: Current and Future Perspectives in Clinical Diagnosis and Public Health","volume":"38","author":"Kao C. L.","year":"2005","journal-title":"Journal of Microbiology, Immunology, and Infection = Wei mian yu gan ran za zhi"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2003.11.002"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2021.1935327"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0008603"},{"key":"e_1_2_15_42_1","unstructured":"\u201cWho Are the Middle Class in Bangladesh? \u201d The Business Standard [Internet] January 31 2024 https:\/\/www.tbsnews.net\/feature\/panorama\/who-are-middle-class-bangladesh-141073."},{"key":"e_1_2_15_43_1","article-title":"Clinical and Haematological Profile of Dengue Among Adult Patients at a Tertiary Care Hospital in Pokhara","author":"Dhungana D.","journal-title":"medRxiv"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.5455\/njcm.20200216053516"},{"key":"e_1_2_15_45_1","first-page":"12","article-title":"Clinico\u2010Hematological Profile of Dengue Fever During the Monsoon of 2016 in Central Kerala","volume":"8","author":"Nair K. R.","year":"2018","journal-title":"International Journal of Health Sciences & Research"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-1141-3"},{"issue":"4","key":"e_1_2_15_47_1","first-page":"928","article-title":"Dengue Virus Serotypes and Epidemiological Features of Dengue Fever in Faisalabad, Pakistan","volume":"34","author":"Ahmed I.","year":"2017","journal-title":"Tropical Biomedicine"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmii.2016.08.024"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.3855\/jidc.2010"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.37268\/mjphm\/vol.20\/no.2\/art.422"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1202.050274"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.03.054"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.125.4.501"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13104-019-4655-8"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.4084\/mjhid.2018.021"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.01.029"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-018-2996-x"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.18203\/2349-3291.ijcp20210659"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.11.3.480"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.70356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T12:30:57Z","timestamp":1764160257000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.70356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":58,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1002\/hsr2.70356"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.70356","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"2023-10-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70356"}}