{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T20:23:40Z","timestamp":1780086220511,"version":"3.54.0"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aims<\/jats:title>\n                    <jats:p>\n                      Urinary tract infections (UTIs) are a prevalent bacterial infection that has substantial implications for healthcare on a global scale.\n                      <jats:italic>Escherichia coli<\/jats:italic>\n                      (\n                      <jats:italic>E. coli<\/jats:italic>\n                      ) is a gram\u2010negative rod responsible for most UTI cases. ESBL\u2010producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      is widely recognized as a significant contributor to antibiotic resistance. This study aims to evaluate the prevalence and antibiotic resistance trends of ESBL\u2010producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      in patients with UTIs at a tertiary hospital in Jazan, Saudi Arabia.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective cross\u2010sectional analysis was conducted on 347 urine specimens collected between January 2022 and March 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study found that 31% of\n                      <jats:italic>E. coli<\/jats:italic>\n                      specimens were positive for ESBL. Among patients with ESBL\u2010producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      , 78.9% were females, and the majority of ESBL\u2010producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      cases were observed in the outpatient clinic departments. Among all\n                      <jats:italic>E. coli<\/jats:italic>\n                      isolates, ampicillin exhibited the highest resistance rate at 69.3%, aztreonam at 66.7%, and colistin at the lowest resistance. ESBL\u2010producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      strains exhibited higher resistance rates than non\u2010ESBL\u2010producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      strains.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      The study agrees with others in the region and shows a higher prevalence of ESBL\u2010producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      in the region, emphasizing the importance of antibiotic stewardship programs and infection control measures to mitigate the prevalence and spread of ESBL\u2010producing\n                      <jats:italic>E. coli<\/jats:italic>\n                      in our region.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/hsr2.70378","type":"journal-article","created":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T01:37:12Z","timestamp":1737682632000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Retrospective Analysis of Antibiotic Resistance Patterns of Uropathogenic\n                    <i>Escherichia coli<\/i>\n                    With Focus on Extended\u2010Spectrum\n                    <i>\u03b2<\/i>\n                    \u2010Lactamase at a Tertiary Central Hospital in Saudi Arabia"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-3998-6135","authenticated-orcid":false,"given":"Khalid M.","family":"Alameer","sequence":"first","affiliation":[{"name":"Faculty of Medicine Jazan University Jazan Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bandar M.","family":"Abuageelah","sequence":"additional","affiliation":[{"name":"General 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