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The Asteraceae family is one of the most extensively utilized medicinal plant families due to its abundance and diversity of bioactive secondary metabolites. The aim of this article is to review the current understanding of the allergic potential of the most significant medicinal plant species belonging to the Asteraceae family.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This review utilized various search engines, including PubMed Central, Cochrane Central, Google Scholar, and others, up to January 2024, considering only articles in English.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Asteraceae have long been acknowledged as important sensitizers within occupational environments, eliciting both immediate and delayed hypersensitivity reactions. Recent investigations have indicated the presence of panallergens in Asteraceae pollen, predominantly identified in <jats:italic>Ambrosia artemisiifolia<\/jats:italic> and <jats:italic>Artemisia<\/jats:italic> spp., which are pervasive across many species within the family. These panallergens contribute to cross\u2010reactivity phenomena, serving as primary triggers for pollinosis and pollen\u2010food or pollen\u2010medicine allergy syndrome. In addition, the diverse array of secondary metabolites present in the Asteraceae family, particularly sesquiterpene lactones (SLs), possesses sensitizing properties capable of inducing skin irritation and inflammation. Moreover, SLs have the potential to incite systemic reactions, posing a risk to sensitized individuals upon ingestion. Although extensive cross\u2010reactivity among SLs has been reported, further investigations are warranted to elucidate the underlying mechanisms and implications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As numerous uncertainties persist regarding critical Asteraceae allergens and sensitizers further research is critical to augment our understanding of the potential risks posed by Asteraceae herbal medicine.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70398","type":"journal-article","created":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T09:29:04Z","timestamp":1740562144000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Allergic Potential of Medicinal Plants From the Asteraceae Family"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-0181-7859","authenticated-orcid":false,"given":"Tim","family":"Klju\u010dev\u0161ek","sequence":"first","affiliation":[{"name":"The Department of Pharmaceutical Biology, Faculty of Pharmacy University of Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samo","family":"Kreft","sequence":"additional","affiliation":[{"name":"The Department of Pharmaceutical Biology, Faculty of Pharmacy University of Ljubljana Ljubljana Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22063009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/70.3.491s"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00852"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.6084\/m9.figshare.7697834"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0536.2002.470401.x"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-019-04146-w"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000527481"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cea.13682"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11882-015-0565-6"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/ACI.0000000000000384"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cod.12458"},{"key":"e_1_2_10_13_1","unstructured":"\u201cA Guideline on Summary of Product Characteristics (SmPC) \u201d European Commission Revision 2 accessed May 8 2024 https:\/\/health.ec.europa.eu\/system\/files\/2016-11\/smpc_guideline_rev2_en_0.pdf."},{"key":"e_1_2_10_14_1","unstructured":"\u201cFinal Assessment Report on Matricaria recutita L. flos and Matricaria recutita L. aetheroleum (First Version) \u201d European Medicines Agency accessed March 14 2023 https:\/\/www.ema.europa.eu\/en\/documents\/herbal-report\/final-assessment-report-matricaria-recutita-l-flos-and-matricaria-recutita-l-aetheroleum-first-version_en.pdf-0."},{"key":"e_1_2_10_15_1","unstructured":"\u201cFinal Assessment Report on Arnica montana L. flos \u201d European Medicines Agency accessed March 14 2023 https:\/\/www.ema.europa.eu\/en\/documents\/herbal-report\/final-assessment-report-arnica-montana-l-flos_en.pdf."},{"key":"e_1_2_10_16_1","unstructured":"\u201cFinal Assessment Report on Taraxacum officinale (F.H. 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