{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T13:02:17Z","timestamp":1785157337960,"version":"3.55.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Schistosomiasis is a chronic neglected tropical disease and Ghana's second most prevalent helminth infection. The annual mass drug administration of praziquantel to school children is aimed at reducing disease morbidity as a public health problem.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The study aimed to assess the prevalence and hematological profile of urinary schistosomiasis in Sempoa after over a decade of consecutive Mass Drug Administration (MDA) of praziquantel.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A community\u2010based cross\u2010sectional study involving 126 participants was conducted. <jats:italic>Schistosoma haematobium<\/jats:italic> eggs were identified and quantified using the urine filtration\u2010microscopy technique. The hematological profile was analyzed using a fully automated 5\u2010part Sysmex XN\u2010350 (Sysmex Co, Germany) analyzer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study recorded a prevalence of 21.6% that was significantly related to water contact activities. Schistosomiasis was significantly associated with lower levels of Red Blood Cell (RBC) indices; MCV (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), MCHC (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and MCH (<jats:italic>p<\/jats:italic>\u2009=\u20090.01) with higher platelet, lymphocytes, and basophil counts compared to the uninfected. Heavy infection was significantly associated with lower hemoglobin levels. The study further reported microhaematuria as a sensitive and specific proxy diagnostic tool for field surveillance in endemic communities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Urinary schistosomiasis accompanied by an altered hematological profile persists in Sempoa under preventive praziquantel. Future control interventions must consider an integrated approach of marrying behavioral change, with preventive chemotherapy and vector control.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70404","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T05:55:11Z","timestamp":1738216511000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence and Hematological Changes in Urogenital Schistosomiasis: Infection Persistence in the Phase of Mass Drug Administration in Sempoa (Kwahu East, Ghana): A Cross\u2010Sectional Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7715-8063","authenticated-orcid":false,"given":"Alahaman Nana","family":"Boakye","sequence":"first","affiliation":[{"name":"Department of Health and Allied Sciences Baldwin University College  Accra Ghana"},{"name":"Department of Clinical Microbiology, School of Medicine University for Development Studies Tamale Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neuwell","family":"Hatsu","sequence":"additional","affiliation":[{"name":"Department of Health and Allied Sciences Baldwin University College  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8723-2271","authenticated-orcid":false,"given":"Samuel Addo","family":"Akwetey","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, School of Medicine University for Development Studies Tamale Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akosua Bonsu","family":"Karikari","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology, School of Medicine University for Development Studies Tamale Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon Kwaku","family":"Atta","sequence":"additional","affiliation":[{"name":"Department of Health and Allied Sciences Baldwin University College  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark Michael","family":"Addae","sequence":"additional","affiliation":[{"name":"Department of Health and Allied Sciences Baldwin University College  Accra Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization accessed 16 July2020.https:\/\/www.who.int\/health-topics\/schistosomiasis."},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0031182009990400"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.11604\/pamj.2020.35.131.21069"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-385897-9.00005-7"},{"key":"e_1_2_12_6_1","volume-title":"Schistosomiasis Progress Report 2001\u20132011 and Strategic Plan 2012\u20132020","author":"World Health Organization","year":"2013"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0005524"},{"issue":"2","key":"e_1_2_12_8_1","first-page":"59","article-title":"Haematological and Biochemical Morbidity of Schistosoma Haematobium in School Children in Sudan","volume":"6","author":"Mohammed E. 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