{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:30Z","timestamp":1753869270902,"version":"3.41.2"},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>To determine the effect of prophylactic intravenous tranexamic acid on blood loss after vaginal delivery in women at low risk of postpartum hemorrhage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective randomized controlled study (RCT registration: researchregistry10144). Over the study duration of 12 months, a total of 226 parous women with singleton vaginal delivery at term pregnancy with cephalic presentation participated in the study. Participants with pre\u2010existing medical complications and obstetric complications were excluded from the study. Additionally, patients with a previous history of thromboembolism and allergy to tranexamic acid were also excluded from the study. The study participants were divided into two groups based on the intervention considered. This was done with a computer\u2010based random table generator. Group A received an intervention of 10\u2009mL (1\u2009g) of intravenous tranexamic acid while the other group received 10\u2009mL of normal saline as a placebo immediately after delivery of the fetus. Blood loss was calculated by measuring the weights of blood\u2010soaked gauze, gowns, sheets, and tampons before and after delivery. Hemoglobin and hematocrit were done before and 12\u2009h after delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Total number of participants were 226. The mean calculated blood loss and the mean measured blood loss was significantly less in Group A in comparison to Group B (379.17\u2009\u00b1\u200946.89\u2009mL in Group A and 426.66\u2009\u00b1\u200958.45\u2009mL in Group B, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), (247.88\u2009\u00b1\u200967.03\u2009mL in Group A and 368.95\u2009\u00b1\u200958.54\u2009mL in group B, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Similarly, the mean decrease of hemoglobin after delivery was lower for Group A (1.45\u2009\u00b1\u20090.14) than for Group B (1.74\u2009\u00b1\u20090.24).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The use of prophylactic intravenous tranexamic acid is associated with reduced blood loss after vaginal delivery. Furthermore, research needs to be done.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70415","type":"journal-article","created":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T05:49:35Z","timestamp":1738216175000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effect of Prophylactic Intravenous Tranexamic Acid on Blood Loss After Vaginal Delivery: A Randomized Control Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-9332-8840","authenticated-orcid":false,"given":"Sajana","family":"Shrestha","sequence":"first","affiliation":[{"name":"Tree Top Hospital Hulhumale Maldives"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shelisha","family":"Uprety","sequence":"additional","affiliation":[{"name":"Helping Hand Community Hospital Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2923-181X","authenticated-orcid":false,"given":"Ravi","family":"Shah","sequence":"additional","affiliation":[{"name":"Nepalese Army Institute of Health Sciences Kathmandu Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brinda","family":"Kharel","sequence":"additional","affiliation":[{"name":"National Medical College Birgunj Nepal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aei066"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0020-7292(96)02667-7"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.e3054"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldg015"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.33.Suppl_14.35"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-199957060-00017"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(96)00022-7"},{"issue":"6","key":"e_1_2_13_9_1","first-page":"612","article-title":"Effects of Tranexamic Acid on Death, Vascular Occlusive Events, and Blood Transfusion in Trauma Patients With Significant Haemorrhage (CRASH\u20102): A Randomised, Placebo\u2010Controlled Trial","volume":"59","author":"Williams\u2010Johnson J. A.","year":"2010","journal-title":"West Indian Medical Journal"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/sja.SJA_559_18"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(03)00287-2"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajo.12262"},{"key":"e_1_2_13_13_1","unstructured":"\u201cWHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage: Highlights and Key Messages [Internet] \u201d March 12 2024 https:\/\/www.who.int\/publications-detail-redirect\/WHO-RHR-17.21."},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.04.016"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aeu448"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.whi.2008.09.008"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12636"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(97)70266-7"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2011.07.015"},{"issue":"10","key":"e_1_2_13_20_1","first-page":"590","article-title":"[Clinical Study on the Efficacy of Tranexamic Acid in Reducing Postpartum Blood Lose: A Randomized, Comparative, Multicenter Trial]","volume":"36","author":"Yang H.","year":"2001","journal-title":"Zhonghua Fu Chan Ke Za Zhi"},{"issue":"5","key":"e_1_2_13_21_1","first-page":"407","article-title":"Can Intravenous Injection of Tranexamic Acid Be Used in Routine Practice With Active Management of the Third Stage of Labor in Vaginal Delivery? A Randomized Controlled Study","volume":"30","author":"Gungorduk K.","year":"2013","journal-title":"American Journal of Perinatology"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.12816\/0042235"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eclinm.2024.102665"},{"issue":"3","key":"e_1_2_13_24_1","first-page":"283","article-title":"Incidence of Pulmonary and\/or Systemic Thromboembolism in Pregnancy","volume":"42","author":"Pan\u0103 R. 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