{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:36:23Z","timestamp":1780353383188,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Cardiovascular diseases (CVDs), encompassing a variety of conditions affecting the heart and blood vessels, remain a significant global public health challenge. Among various therapeutic options, Coenzyme Q10 (CoQ10) has garnered attention due to its potential benefits for cardiovascular health. CoQ10 is a naturally occurring antioxidant that plays a crucial role in cellular energy production and has long been used therapeutically. This study aims to summarize and systematically analyze the scientific literature on glycemic profile, lipid profile, anthropometric measures, blood pressure, inflammatory factors, liver function tests, oxidative stress parameters and adipokines associated with CoQ10 supplementation to provide a basis for clinical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic electronic search will be conducted to identify articles published from inception to July 2024 across databases including PubMed, Scopus, Web of Science, CENTRAL, and EMBASE. The search will focus on randomized controlled trials (RCTs) involving both healthy and unhealthy participants. Two independent reviewers will evaluate articles, extract data, and assess study quality using the Cochrane risk of bias tool. Discrepancies will be resolved through consultation with a third reviewer. If a sufficient number of eligible studies are identified, a meta\u2010analysis will be performed on the selected outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results will provide a comprehensive synthesis of the effects of CoQ10 supplementation on cardiovascular disease risk factors, including glycemic profile, lipid profile, anthropometric measures, blood pressure, inflammatory factors, liver function tests, oxidative stress parameters, and adipokines.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This protocol outlines a comprehensive approach to systematically review and perform a dose\u2013response meta\u2010analysis on the effects of CoQ10 supplementation on CVD risk factors. The study will employ rigorous methodologies, including independent evaluation and GRADE assessment, to ensure high\u2010quality evidence synthesis from RCTs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70452","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T01:14:26Z","timestamp":1739236466000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Can Coenzyme Q10 Supplementation Reduce Cardiovascular Disease Risk Factors? A Protocol for a GRADE\u2010Assessed Systematic Review and Dose\u2010Response Meta\u2010Analysis of Randomized Controlled Trials"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7343-027X","authenticated-orcid":false,"given":"Ali","family":"Jafari","sequence":"first","affiliation":[{"name":"Student Research Committee, Department of Community Nutrition, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute Shahid Beheshti University of Medical Sciences Tehran Iran"},{"name":"Systematic Review and Meta\u2010analysis Expert Group (SRMEG), Universal Scientific Education and Research Network (USERN) Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2023.11.007"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIR.0000000000000950"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573403X14666180222102312"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612825666190925163827"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2023-080926"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8340"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox10060906"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9040341"},{"key":"e_1_2_9_10_1","first-page":"1","article-title":"An Insight Into Pathogenesis of Cardiovascular Diseases","volume":"03","author":"Zafar R.","year":"2015","journal-title":"Journal of Cardiovascular Diseases & Diagnosis"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnesp.2024.01.015"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1191290"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgac585"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/advances\/nmac100"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3478"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15183990"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1191290"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.3315"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g7647"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.l4898"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/jrsm.1411"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000132"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2012.01.006"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119536604"}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.70452","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:03:55Z","timestamp":1741745035000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.70452"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["10.1002\/hsr2.70452"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.70452","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"2024-07-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-01-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70452"}}