{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:40:33Z","timestamp":1788950433704,"version":"build-2803163510"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,4]],"date-time":"2025-03-04T00:00:00Z","timestamp":1741046400000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Influenza mortality rates varying across different populations. This study aims to assess influenza lethality in hospitalized adults (\u2265\u200915 years) and identify key risk factors according to age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We designed a retrospective study at Dr. Balmis General University Hospital (Alicante, Spain), including patients hospitalized for influenza from 2016 to 2022. In\u2010hospital death was expressed as the case fatality rate (CFR). Variables yielding a <jats:italic>p<\/jats:italic> value under 0.1 on univariable analysis were included in the multivariable logistic regression model to identify risk factors for lethality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 1613 patients admitted for influenza (incidence 86 per 10,000 admissions), 96 died (CFR 5.95%). Lethality increased with age, reaching 8.4% in patients aged 80\u201389 years and 19.5% in those over 90. In all of the cohort, risk factors were age, dementia, respiratory failure, influenza pneumonia, and sepsis, while treatment with oseltamivir acted as a protective factor. In patients &lt;\u200980 years of age, risk factors were neoplasia, respiratory failure, and influenza pneumonia, whereas oseltamivir treatment was a protective factor. In patients 80 years (<jats:italic>n<\/jats:italic>\u2009=\u2009554; 34.3%), the risk of mortality increased with age, dementia, respiratory failure, noninfluenza pneumonia, and sepsis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Influenza deaths increase with age; this relationship is accentuated in people aged 80 or older. Respiratory failure was the main risk factor in all patients hospitalized for influenza. Treatment with oseltamivir protected patients (especially those &lt;\u200980 years) against deaths. Patients &lt;\u200980 years\u2010old carried a higher risk of death if they had a neoplasia, whereas in \u2265\u200980 patients, the risk was associated with dementia and noninfluenza pneumonia.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70458","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T21:25:23Z","timestamp":1741728323000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["In\u2010Hospital Death and Risk Factors in Adults With Influenza in Spain (2016\u20132022): A Cross\u2010Sectional Study With Focus on Older Patients"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6501-9867","authenticated-orcid":false,"given":"Jose\u2010Manuel","family":"Ramos\u2010Rincon","sequence":"first","affiliation":[{"name":"Clinical Medicine Department University Miguel Hern\u00e1ndez of Elche Elche Spain"},{"name":"Internal Medicine Department, Dr. Balmis 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Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0921-1854","authenticated-orcid":false,"given":"Fatima","family":"Valero\u2010Sempere","sequence":"additional","affiliation":[{"name":"Internal Medicine Department, Dr. Balmis General University Hospital Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5694-8162","authenticated-orcid":false,"given":"Diego","family":"Torr\u00fas","sequence":"additional","affiliation":[{"name":"Unit of Infectious Diseases, Dr. Balmis General University Hospital Alicante Institute for Health and Biomedical Research (ISABIAL) Alicante Spain"},{"name":"Parasitology Area University Miguel Hern\u00e1ndez of Elche Elche Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Valero\u2010Novella","sequence":"additional","affiliation":[{"name":"Internal 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