{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:35Z","timestamp":1753869275117,"version":"3.41.2"},"reference-count":50,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Soluble forms of progenitor cell receptors may be implicated in the delayed erythropoietic response during severe anemia. In this study, plasma levels of soluble erythropoietin receptor (sEPO\u2010R) and soluble granulocyte, macrophage\u2010colony stimulating factor receptor (sGM\u2010CSFR) were assessed in <jats:italic>Plasmodium falciparum\u2010<\/jats:italic>infected children in Ghana.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This case\u2010control study was conducted at Tamale Teaching Hospital, Ghana. One hundred and twenty <jats:italic>P. falciparum\u2010<\/jats:italic>infected, and 60 uninfected children aged 12\u2013144 months were recruited from April to July, 2023. About 4\u2009mL of blood was collected for malaria microscopy, full blood count using a haematology analyser, and sEPO\u2010R, sGM\u2010CSFR and erythropoietin (EPO) estimation using enzyme\u2010linked immunosorbent assays. Data were analyzed using SPSS version 26.0.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Plasma levels of sEPO\u2010R were higher among participants with severe malarial anemia (SMA) than those in the non\u2010SMA and control groups (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Plasma sGM\u2010CSFR levels were higher in <jats:italic>P. falciparum\u2010<\/jats:italic>infected children than in controls, but the levels were similar between the SMA and non\u2010SMA groups. Hemoglobin (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.823, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), RBC (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.852, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), HCT (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.790, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and platelets (<jats:italic>r<\/jats:italic>\u2009=\u2009\u22120.810, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) negatively correlated with sEPO\u2010R. There was a strong positive correlation between sEPO\u2010R and EPO in <jats:italic>P. falciparum\u2010<\/jats:italic>infected children (<jats:italic>r<\/jats:italic>\u2009=\u20090.901, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Plasma sEPO\u2010R better predicted severe anemia among malaria\u2010infected children (cut\u2010off point: 161.5\u2009pg\/mL, sensitivity: 96.0%, specificity: 82.9%, AUC: 0.964, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p><jats:italic>P. falciparum<\/jats:italic>\u2010infected children had higher plasma levels of sGM\u2010CSFR, sEPO\u2010R and EPO. Plasma sEPO\u2010R correlated negatively with erythrocyte parameters, suggesting a possible contribution of the endogenous receptor to the development of severe anemia in children with malaria. Further studies to investigate the neutralizing effects of sEPO\u2010R on erythropoietic response during malaria are recommended.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70460","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T06:58:57Z","timestamp":1739257137000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plasma Soluble Progenitor Cell Receptors as Biomarkers for Severe Anemia Among Malaria\u2010Infected Pediatrics: A Prospective Study in Ghana"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6986-9976","authenticated-orcid":false,"given":"Charles","family":"Nkansah","sequence":"first","affiliation":[{"name":"Department of Haematology School of Allied Health Sciences, University for Development Studies Tamale Ghana"},{"name":"Department of Medical Laboratory Science Faculty of Health Science and Technology, Ebonyi State University 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