{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T13:52:38Z","timestamp":1789912358902,"version":"4.0.1"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,2]],"date-time":"2025-03-02T00:00:00Z","timestamp":1740873600000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Alterations in the expression pattern of miRNAs seem to be linked with autoimmune diseases such as type 1 diabetes mellitus (T1DM). Regarding the importance of assessing this potential link, we aimed to evaluate the relationship between <jats:italic>miR\u201021 rs1292037<\/jats:italic> single\u2010nucleotide polymorphism (SNP) and T1DM susceptibility. Furthermore, we investigated the <jats:italic>miR\u201021<\/jats:italic> expression level in T1DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 250 T1DM patients and 250 controls were genotyped using polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP) and miR\u201021 expression levels were assessed using real\u2010time PCR. Moreover, the potential targets of miR\u201021 were investigated using different bioinformatics web servers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Our results showed that the T\/C genotype and the C allele were more frequent in T1DM patients than in controls. Individuals carrying the T\/C genotype in overdominant model were 2.74\u2010fold at a higher risk of T1DM (OR\u2009=\u20092.74; 95%CI, 1.78\u20134.27; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). In addition, miR\u201021 expression was more than twofold higher in patients than in controls (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and it was found to be significantly upregulated when carrying the T\/C genotype. Regarding miR\u201021 predicted target genes, its overexpression may be associated with beta cell death, diabetic nephropathy, inflammatory responses, impaired insulin production or secretion, and T\u2010cell cytotoxicity, which are important in the initiation and progression of T1DM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results suggested that miR\u201021 <jats:italic>rs1292037<\/jats:italic> may confer genetic susceptibility to T1DM. Therefore, it seems that this genetic link should be further investigated to enhance diagnostic and therapeutic strategies in these patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70480","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T16:42:54Z","timestamp":1741711374000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Influence of rs<i>1292037<\/i> Genetic Variant on miR\u201021 Gene Expression in Patients With Type 1 Diabetes Mellitus: A Case\u2010Control Study"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8956-5205","authenticated-orcid":false,"given":"Reza","family":"Bayat","sequence":"first","affiliation":[{"name":"Department of Biology, University Campus2 University of Guilan Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6925-5103","authenticated-orcid":false,"given":"Zivar","family":"Salehi","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences University of Guilan Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Setila","family":"Dalili","sequence":"additional","affiliation":[{"name":"Pediatric Diseases Research Center Guilan University of Medical Sciences Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Mashayekhi","sequence":"additional","affiliation":[{"name":"Department of Biology, Faculty of Sciences University of Guilan Rasht 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