{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T01:10:46Z","timestamp":1791940246755,"version":"4.3.4"},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T00:00:00Z","timestamp":1739923200000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aim<\/jats:title><jats:p>Type 2 diabetes mellitus (T2DM) remains one of the major causes of morbidity and mortality worldwide, including Bangladesh. SIRT1, an NAD\u2010dependent deacetylase, is involved in energy homeostasis and protects \u03b2\u2010cells of the pancreas from oxidative stress. Single nucleotide polymorphisms (SNPs) in the <jats:italic>SIRT1<\/jats:italic> gene have been found to be associated with T2DM in several populations, however, with conflicting results. The aim of this present case\u2010control study, along with the meta\u2010analysis, was to elucidate the association of rs3758391 polymorphism with the susceptibility to T2DM in Bangladeshi population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>72 T2DM patients and 90 healthy controls were enrolled in our study and polymerase chain reaction\u2010restriction fragment length polymorphism (PCR\u2010RFLP) was employed for genotyping the SNP. Odds ratio (OR) with 95% confidence interval (95% CI) was used to represent the association of <jats:italic>SIRT1<\/jats:italic> polymorphism with T2DM. For the meta\u2010analysis six studies were included and pooled odds ratio with 95% CI were calculated for six genetic models using the random effects model. Heterogeneity and publication bias was also calculated for each study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A significant association was found between rs3758391 polymorphism and increased risk of T2DM under codominant TT versus CC (OR\u2009=\u20093.88, 95% CI\u2009=\u20091.34\u201311.25, <jats:italic>p<\/jats:italic>\u2009=\u20090.012), recessive TT versus CC\u2009+\u2009CT (OR\u2009=\u20092.83, 95% CI\u2009=\u20091.12\u20137.09, <jats:italic>p<\/jats:italic>\u2009=\u20090.027) and allelic T versus C (OR\u2009=\u20091.67, 95% CI\u2009=\u20091.07\u20132.60, <jats:italic>p<\/jats:italic>\u2009=\u20090.024) genetic models. However, no significant association between rs3758391 and other biochemical and anthropometric parameters were found. Our meta\u2010analysis showed no statistically significant association of this polymorphism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that, polymorphism at rs3758391 of <jats:italic>SIRT1<\/jats:italic> gene conferred an increased risk of T2DM in Bangladeshi population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70495","type":"journal-article","created":{"date-parts":[[2025,2,20]],"date-time":"2025-02-20T04:50:21Z","timestamp":1740027021000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Association of <i>SIRT1<\/i> rs3758391 Polymorphism With T2DM in Bangladeshi Population: Evidence From a Case\u2010Control Study and Meta\u2010Analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9350-5033","authenticated-orcid":false,"given":"Rezwana","family":"Ahmed","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences North South University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mushfikur Rahman","family":"Safa","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences North South University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahidul Islam","family":"Zahid","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences North South University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Mazharul Islam","family":"Chowdhury","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences North South University Dhaka Bangladesh"},{"name":"Appalachian College of Pharmacy Oakwood Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.B.M. Kamrul","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Endocrinology Mymensingh Medical College Mymensingh Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9229-651X","authenticated-orcid":false,"given":"Md. Shaki","family":"Mostaid","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences North South University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hasan Mahmud","family":"Reza","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences North South University Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)01301-6"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1797-8"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc15-1585"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21176275"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00618-8"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)30058-2"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18642"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0906948"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1474-9726.2010.00548.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pathol.4.110807.092250"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2007.07.032"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03354"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(04)00126-6"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1094637"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.081067"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600244"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.014"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2006.04.002"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099196"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms1001"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.08.022"},{"issue":"2","key":"e_1_2_11_23_1","first-page":"210","article-title":"Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic \u03b2 Cells","volume":"4","author":"Bordone L.","year":"2006","journal-title":"PLoS Biology"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2005.07.001"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2009.101"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.10-173492"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2008.08.017"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.11.013"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114560"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.2217\/fca.11.76"},{"key":"e_1_2_11_31_1","first-page":"1","article-title":"Sirtuins in Osteoarthritis: Current Understanding","volume":"14","author":"Liu Y.","year":"2023","journal-title":"Frontiers in Immunology"},{"issue":"6","key":"e_1_2_11_32_1","first-page":"1","article-title":"The Role of Sirtuin 1 (SIRT1) in Neurodegeneration","volume":"1","author":"Razick D. 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