{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T09:54:36Z","timestamp":1753869276320,"version":"3.41.2"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,3,3]],"date-time":"2025-03-03T00:00:00Z","timestamp":1740960000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hepatitis C virus (HCV) infection is a major global health issue. Injecting drug users (IDUs) are an important group at risk of HCV infection. Therefore, this study was undertaken to determine the related high\u2010risk behavioral factors and the effectiveness of addiction treatment centers in preventing the transmission of HCV among IDUs referring to governmental methadone maintenance treatment (MMT) centers in Southeast Iran.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This analytical study was conducted as a pre\u2010 and post\u2010intervention assessment without a control group in first 6 months of 2022. 313 IDUs receiving methadone from five governmental MMT centers in Kerman were interviewed in the form of a census. Effectiveness was measured using mathematical formulas and patterns based on high\u2010risk injecting behaviors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 313 participants, 299 (95.84%) were men, the mean age\u2009\u00b1\u2009SD was 41.06\u2009\u00b1\u20098.73 years and HCV prevalence was 113 (36.1%). The results showed that MMT centers avoided 23.55 new cases of HCV per 100 people. The studied IDUs reported minor rate of risky injecting and sexual behavior after participation in MMT program. The communal incidence of HCV per 100 IDUs due to shared injection and unsafe sexual connection with MMT program were 13.89 (95% CI: 5.43\u201319.63), 0.0003 (0.0002\u20130.0007) and without it 37.44 (24.34\u201346.78) and 0.0002 (0.0001\u20130.0004) respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The MMT program is an effective intervention to prevent HCV infection, a comparison of its effectiveness with other interventions is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70501","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:52:11Z","timestamp":1741747931000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Finding the Context of High\u2010Risk Behavioral Factors and the Effectiveness of Addiction Treatment Centers in Preventing the Transmission of Hepatitis C Virus Among Injecting Drug Addicts: \u201cSoutheastern Iran\u201d"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7573-0452","authenticated-orcid":false,"given":"Neda","family":"Asadi","sequence":"first","affiliation":[{"name":"Nursing Research Center Kerman University of Medical Sciences Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7155-8488","authenticated-orcid":false,"given":"Sirous","family":"Pourkhajoei","sequence":"additional","affiliation":[{"name":"Faculty of Management and Medical Information Sciences Kerman University of Medical Sciences Kerman Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,3]]},"reference":[{"issue":"28","key":"e_1_2_13_2_1","first-page":"9270","article-title":"Epidemiology and Natural History of Hepatitis C Virus Infection","volume":"20","author":"Lee M. 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