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Vitamin D deficiency is common in T1DM patients and is associated with an increased risk of cardiovascular diseases. This systematic review aimed to evaluate the impact of vitamin D supplementation on BP in T1DM patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>PubMed, Web of Science, Embase, Scopus, and Google Scholar were searched until March 2024. Clinical trials reported BP outcomes in patients with T1DM after vitamin D supplementation were included. Other types of studies and studies that did not report BP outcomes and those that had populations other than patients with T1DM were excluded. The National Institutes of Health (NIH) tool was used for the risk of bias assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, eight studies, involving 328 participants, were included in this review. They were conducted between 2014 and 2024, with mostly conducted in Brazil (<jats:italic>n<\/jats:italic>\u2009=\u20095). While one study demonstrated a significant reduction in morning systolic and diastolic BP after vitamin D supplementation, five studies found no significant differences in systolic or diastolic BP. Another study noted a significant reduction in morning systolic and diastolic BP, with no significant changes in 24\u2010h ambulatory monitoring. Also, paricalcitol therapy did not significantly reduce systolic and diastolic ambulatory BP compared to placebo.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The current evidence on the effect of vitamin D supplementation on blood pressure in patients with T1DM remains inconclusive. Nonetheless, more randomized controlled studies with larger sample sizes and longer follow\u2010up durations are essential to establish the association between vitamin D and BP in this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70524","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T02:48:05Z","timestamp":1741747685000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Effects of Vitamin D Supplementation on Blood Pressure in Patients With Type 1 Diabetes Mellitus: A Systematic Review of Clinical Trials"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0991-7752","authenticated-orcid":false,"given":"Rasoul","family":"Ebrahimi","sequence":"first","affiliation":[{"name":"School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-4243-5698","authenticated-orcid":false,"given":"Mohammad Mahdi","family":"Masouri","sequence":"additional","affiliation":[{"name":"School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2226-4386","authenticated-orcid":false,"given":"Amir Abbas","family":"Salehi Amniyeh Khozani","sequence":"additional","affiliation":[{"name":"School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4004-904X","authenticated-orcid":false,"given":"Sana","family":"Mohammad Soltani","sequence":"additional","affiliation":[{"name":"School of Medicine Shahid Beheshti University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8692-9720","authenticated-orcid":false,"given":"Seyed Aria","family":"Nejadghaderi","sequence":"additional","affiliation":[{"name":"HIV\/STI Surveillance Research Center, and WHO Collaborating Center for HIV Surveillance, Institute for Futures Studies in Health Kerman University of Medical Sciences Kerman Iran"},{"name":"Systematic Review and Meta\u2010analysis Expert Group (SRMEG) Universal Scientific Education and Research Network (USERN) Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.815703"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-021-00641-8"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10081798"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.2174\/18756417MTA2pNTAa1"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12933-022-01568-8"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-0298"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2006.02633.x"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH03-07-0423"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/79.5.820"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2007.03.059"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu15030769"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-021-00593-z"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2012.04.046"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2008.08.020"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24054679"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.14341\/DM12824"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399816999200729131508"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.605681"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.33024\/mnj.v6i2.13219"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP202493"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu10030375"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0213006"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0138237"},{"key":"e_1_2_13_26_1","unstructured":"National Institutes of Health (NIH). 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