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Curcumin (CUR) exhibits antioxidant properties that aid in OS regulation. This systematic review and dose\u2013response meta\u2010analysis of randomized clinical trials (RCTs) evaluated the effects of CUR supplementation on cardiometabolic risk factors in women with PCOS.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search across various databases was implemented to identify eligible RCTs published until January 2024. A meta\u2010analysis was conducted employing a random\u2010effects model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eight RCTs were included in the meta\u2010analysis. It was indicated that CUR supplementation substantially reduced fasting blood sugar (FBS) (standardized mean difference [SMD]: \u22120.40\u2009mg\/dL, 95% confidence interval [CI]: \u22120.59, \u22120.21; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), insulin (SMD: \u22120.32\u2009\u00b5U\/mL, 95% CI: \u22120.49, \u22120.14; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), homeostasis model assessment of insulin resistance (HOMA\u2010IR) (SMD: \u22120.36, 95% CI: \u22120.54, \u22120.19; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and total cholesterol (TC) (SMD: \u22120.34\u2009mg\/dL, 95% CI: \u22120.61, \u22120.08; <jats:italic>p<\/jats:italic>\u2009=\u20090.01). In addition, it substantially increased the quantitative insulin sensitivity check index (QUICKI) (SMD: 0.37, 95% CI: 0.13, 0.61; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) in the CUR\u2010treated group compared with the control group. However, CUR did not have significant impacts on body mass index (BMI), body weight, serum levels of follicle\u2010stimulating hormone (FSH), triglycerides (TG), dehydroepiandrosterone (DHEA), high\u2010density lipoprotein (HDL), testosterone, low\u2010density lipoprotein (LDL), and luteinizing hormone (LH).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study revealed that CUR may have the potential to enhance cardiometabolic health by reducing hyperglycemia, insulin resistance, and serum TC levels in women with PCOS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70525","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T02:55:38Z","timestamp":1741661738000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Impacts of Curcumin Supplementation on Cardiometabolic Risk Factors in Patients With Polycystic Ovary Syndrome: A Systematic Review and Dose\u2212Response Meta\u2010Analysis"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9157-1922","authenticated-orcid":false,"given":"Shooka","family":"Mohammadi","sequence":"first","affiliation":[{"name":"Nutrition and Metabolic Diseases Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran"},{"name":"Department of Social and Preventive Medicine Faculty of Medicine, University of Malaya Kuala Lumpur Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Somayeh","family":"Ziaei","sequence":"additional","affiliation":[{"name":"Departemt of Anesthesia, Imam Reza Hospital Kermanshah University of Medical Sciences Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrnaz","family":"Morvaridi","sequence":"additional","affiliation":[{"name":"School of Public Health Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motahareh","family":"Hasani","sequence":"additional","affiliation":[{"name":"Department of Nutritional Sciences School of Health, Golestan University of Medical Sciences Gorgan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Mirtaheri","sequence":"additional","affiliation":[{"name":"Department of Human Sciences Human Nutrition Program, The Ohio State University Columbus Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Farsi","sequence":"additional","affiliation":[{"name":"Minimally Invasive Surgery Research Center Iran University of Medical Sciences Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Institute for Physical Activity and Nutrition School of Exercise and Nutrition Sciences, Deakin University Geelong VIC Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elnaz","family":"Daneshzad","sequence":"additional","affiliation":[{"name":"Non\u2010Communicable Diseases Research Center Alborz University of Medical Sciences Karaj Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-0185","authenticated-orcid":false,"given":"Javad","family":"Heshmati","sequence":"additional","affiliation":[{"name":"University of Ottawa Heart Institute Ottawa Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2018.10.003"},{"issue":"3","key":"e_1_2_11_3_1","first-page":"2","article-title":"Cardio Metabolic Syndrome: A Global Epidemic","volume":"6","author":"Kelli H. 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