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This paper aims to raise awareness of this disease association while promoting a clinical\u2010oriented, multidisciplinary approach that can provide long\u2010term benefits for these patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature review was conducted to gather up\u2010to\u2010date evidence concerning the incidence and type of CVDs associated with MS, the mechanisms underlying this disease association, as well as the impact on MS progression. Based on this evidence, a neurocardiological approach to MS in clinical practice was proposed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Past and present research agree on the high rates of arterial hypertension, metabolic syndrome, stroke, and myocardial infarction in people with MS. However, other prevalent comorbidities, such as venous thromboembolism and autonomic dysfunction may be easily overlooked in clinical practice. A complex interplay between genetic predisposition, traditional risk factors, autonomic dysfunction, inflammation, and treatment\u2010related factors likely plays a role in promoting CVDs in MS. The impact of cardiovascular dysfunction on MS progression ranges from subclinical impairments, such as impaired axonal repairing, to overt physical disability and cognitive dysfunction. This paper proposes a neurocardiological approach to the daily clinical practice of MS patients, comprising general lifestyle measures, comorbidity screening at MS diagnosis, extensive work\u2010ups for progressive\/active forms, and selected autonomic dysfunction screening.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>MS is a lifelong disorder that can be associated with a multitude of comorbidities, particularly cardiovascular ones. Along with increased mortality, cardiovascular pathology can adversely affect clinical and radiological\u2010derived MS outcomes. Thus, surveillance and preventative measures are required for this population.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70607","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T05:40:33Z","timestamp":1743054033000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Neurocardiology Update: The Brain\u2013Heart Connection in Multiple Sclerosis\u2014A Narrative Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7205-628X","authenticated-orcid":false,"given":"Nicoleta","family":"Gherghel\u2010Pav\u0103l","sequence":"first","affiliation":[{"name":"4th Department of Internal Medicine \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-586X","authenticated-orcid":false,"given":"Denis","family":"Pav\u0103l","sequence":"additional","affiliation":[{"name":"Department of Psychiatry \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adina D.","family":"Stan","sequence":"additional","affiliation":[{"name":"Department of Neurology \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga H.","family":"Or\u0103\u0219an","sequence":"additional","affiliation":[{"name":"4th Department of Internal Medicine \u201cIuliu Ha\u021bieganu\u201d University of Medicine and Pharmacy Cluj\u2010Napoca Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adela 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