{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T18:22:43Z","timestamp":1791829363353,"version":"4.3.4"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,4,16]],"date-time":"2025-04-16T00:00:00Z","timestamp":1744761600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Health Science Reports"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background and Aims<\/jats:title><jats:p>Neural tube defects (NTDs) are an important global health concern with high morbidity and mortality. Enhancing access to healthcare for children born with NTDs is crucial for improving health systems and service delivery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic review to assess the global prevalence of NTDs and the accessibility of healthcare services. Our search spanned databases like PubMed, EMBASE, and Scopus, focusing on NTD prevalence, healthcare service mapping, and access barriers. We followed a standardized data extraction process, and the study is registered with PROSPERO (CRD42023425843).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 3067 records, 65 studies met our inclusion criteria, mainly focusing on newborns. The study durations range from 6 months to 40 years. The NTD prevalence was between 0.4 and 215.13 per 10,000 births, with Spina Bifida, Anencephaly, and Encephalocele being the most common. The African region was the WHO region with the highest prevalence, while the Western Pacific Region had the lowest prevalence. One study used geospatial mapping to identify healthcare access barriers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study revealed wide disparities in the prevalence rates of NTDs with the African region having the highest prevalence. Geospatial mapping was not used to assess access to healthcare services for children born with NTDs in almost all the studies. This underscores the global challenge of access to surgical care for children born with NTDs and the need for strengthening healthcare services in settings with high prevalences.<\/jats:p><\/jats:sec>","DOI":"10.1002\/hsr2.70620","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T06:13:01Z","timestamp":1744870381000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence of Babies Born With Neural Tube Defects and Geospatial Mapping of Therapeutic Services: A Systematic Review"],"prefix":"10.1002","volume":"8","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9134-5703","authenticated-orcid":false,"given":"Yvan","family":"Zolo","sequence":"first","affiliation":[{"name":"Global Surgery Division Faculty of Health Sciences University of Cape Town Cape Town Western Cape South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalle Ulrich","family":"David","sequence":"additional","affiliation":[{"name":"Global Surgery Division Faculty of Health Sciences University of Cape Town Cape Town Western Cape South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moses","family":"Isiagi","sequence":"additional","affiliation":[{"name":"Global Surgery Division Faculty of Health Sciences University of Cape Town Cape Town Western Cape South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salome","family":"Maswime","sequence":"additional","affiliation":[{"name":"Global Surgery Division Faculty of Health Sciences University of Cape Town Cape Town Western Cape South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,16]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13548"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/9635827"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2021.01.098"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjgh-2018-000875"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10900-016-0298-z"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.4102\/ajod.v5i1.267"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.7189\/jogh.04.010402"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884-021-03848-9"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13031-019-0234-9"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-83864-5_5"},{"key":"e_1_2_18_12_1","unstructured":"\u201cWhat Is Geospatial Mapping? \u201d Azuga [Internet] cited September 21 2023 https:\/\/www.azuga.com\/blog\/what-is-geospatial-mapping."},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-023-00971-z"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0151586"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/0141076814531750"},{"key":"e_1_2_18_16_1","unstructured":"\u201cBirths and Deaths Must Be Registered in Africa \u201d The Lancet Global Health [Internet] cited December 22 2023 https:\/\/www.thelancet.com\/journals\/langlo\/article\/PIIS2214-109X."},{"key":"e_1_2_18_17_1","unstructured":"\u201cDisease Registries \u201d Journal of Public Health International [Internet] cited December 26 2023 https:\/\/openaccesspub.org\/public-health-international\/disease-registries."},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.h5949"},{"issue":"1","key":"e_1_2_18_19_1","first-page":"3","article-title":"Global Burden of Neural Tube Defects, Risk Factors, and Prevention","volume":"26","author":"Flores A.","year":"2014","journal-title":"supplement, Indian Journal of Community Health"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70110-8"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23168"},{"key":"e_1_2_18_22_1","unstructured":"\u201cRethinking Healthcare in Africa With Geospatial Mapping \u201d Gavi the Vaccine Alliance [Internet] cited September 21 2023 https:\/\/www.gavi.org\/vaccineswork\/rethinking-healthcare-africa-geospatial-mapping."},{"key":"e_1_2_18_23_1","unstructured":"AssetWorks \u201cImportance of Geospatial Data Services in Real\u2010Time Asset Tracking [Internet] \u201d cited September 21 2023 https:\/\/utilitiesone.com\/importance-of-geospatial-data-services-in-real-time-asset-tracking."}],"container-title":["Health Science Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/hsr2.70620","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,5]],"date-time":"2025-05-05T02:26:44Z","timestamp":1746412004000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/hsr2.70620"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/hsr2.70620"],"URL":"https:\/\/doi.org\/10.1002\/hsr2.70620","archive":["Portico"],"relation":{},"ISSN":["2398-8835","2398-8835"],"issn-type":[{"value":"2398-8835","type":"print"},{"value":"2398-8835","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2025-01-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70620"}}